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Cell wall anchoring in\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            occurs by a transpeptidation mechanism requiring surface proteins with C-terminal sorting signals as well as sortase enzymes. The genome sequence of\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            encodes three sortase genes and eleven surface proteins with different types of cell wall sorting signals. Purified\n            <jats:italic>B. anthracis<\/jats:italic>\n            sortase A cleaved peptides encompassing LPXTG motif-type sorting signals between the threonine (T) and the glycine (G) residues in vitro. Sortase A activity could be inhibited by thiol-reactive reagents, similar to staphylococcal sortases.\n            <jats:italic>B. anthracis<\/jats:italic>\n            parent strain Sterne 34F\n            <jats:sub>2<\/jats:sub>\n            , but not variants lacking the\n            <jats:italic>srtA<\/jats:italic>\n            gene, anchored the collagen-binding MSCRAMM (microbial surface components recognizing adhesive matrix molecules) BasC (BA5258\/BAS4884) to the bacterial cell wall. These results suggest that\n            <jats:italic>B. anthracis<\/jats:italic>\n            SrtA anchors surface proteins bearing LPXTG motif sorting signals to the cell wall envelope of vegetative bacilli.\n          <\/jats:p>","DOI":"10.1128\/jb.187.13.4646-4655.2005","type":"journal-article","created":{"date-parts":[[2005,6,20]],"date-time":"2005-06-20T22:38:06Z","timestamp":1119307086000},"page":"4646-4655","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":74,"title":["<i>Bacillus anthracis<\/i>\n            Sortase A (SrtA) Anchors LPXTG Motif-Containing Surface Proteins to the Cell Wall Envelope"],"prefix":"10.1128","volume":"187","author":[{"given":"Andrew H.","family":"Gaspar","sequence":"first","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano A.","family":"Marraffini","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics &amp; Cell Biology, University of Chicago, 920 East 58th Street, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Glass","sequence":"additional","affiliation":[{"name":"Mathematics and Computer Sciences Division, Argonne National Laboratory, Argonne, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin L.","family":"DeBord","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung","family":"Ton-That","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Schneewind","sequence":"additional","affiliation":[{"name":"Department of Microbiology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.17.5865-5875.2004"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.8.2181-2191.2002"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.7.1972-1982.2004"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1046\/j.1365-2958.2002.02798.x","volume":"43","year":"2002","unstructured":"Bierne, H., S. 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