{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:12:31Z","timestamp":1777961551803,"version":"3.51.4"},"reference-count":37,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T00:00:00Z","timestamp":1139961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[2006,2,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Quorum-sensing systems that have been widely identified in bacteria play important roles in the regulation of bacterial multicellular behavior by which bacteria sense population density to control various biological functions, including virulence. One characteristic of the\n                    <jats:italic>luxIR<\/jats:italic>\n                    quorum-sensing genes is their diverse and discontinuous distribution among proteobacteria. Here we report that the\n                    <jats:italic>spnIR<\/jats:italic>\n                    quorum-sensing system identified in the enterobacterium\n                    <jats:italic>Serratia marcescens<\/jats:italic>\n                    strain SS-1 is carried in a transposon, Tn\n                    <jats:italic>TIR<\/jats:italic>\n                    , which has common characteristics of Tn\n                    <jats:italic>3<\/jats:italic>\n                    family transposons and is mobile between chromosomes and plasmids of different enterobacterial hosts. SpnIR functions in the new host and was shown to negatively regulate the Tn\n                    <jats:italic>TIR<\/jats:italic>\n                    transposition frequency. This finding may help reveal the horizontal transfer and evolutionary mechanism of quorum-sensing genes and alter the way that we perceive regulation of bacterial multicellular behavior.\n                  <\/jats:p>","DOI":"10.1128\/jb.188.4.1518-1525.2006","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T14:40:30Z","timestamp":1138804830000},"page":"1518-1525","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["A Mobile Quorum-Sensing System in\n                    <i>Serratia marcescens<\/i>"],"prefix":"10.1128","volume":"188","author":[{"given":"Jun-Rong","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Huan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Tze","family":"Horng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Chi","family":"Soo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang-Chen","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Ren","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim-Tong","family":"Horng","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Chang Gung University, 259, Wen-Hwa First Road, Kweishan, Taoyuan, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Williams","sequence":"additional","affiliation":[{"name":"Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, NG7 2RD, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin-Chih","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"},{"name":"Department of Laboratory Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"crossref","first-page":"12554","DOI":"10.1073\/pnas.0505835102","volume":"102","year":"2005","unstructured":"Auchtung, J. 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