{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T15:20:40Z","timestamp":1767626440463},"reference-count":3,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1963,1,1]],"date-time":"1963-01-01T00:00:00Z","timestamp":-220924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1963,1]]},"abstract":"\n Formal, Samuel<\/jats:sc>\n B. (Walter Reed Army Institute, Washington, D.C.), G. D.\n Abrams, H. Schneider, and H. Sprinz<\/jats:sc>\n . Experimental\n Shigella<\/jats:italic>\n infections. VI. Role of the small intestine in an experimental infection in guinea pigs. J. Bacteriol.\n 85:<\/jats:bold>\n 119\u2013125. 1963.\u2014\n Shigella<\/jats:italic>\n infection under the conditions of our experiment significantly involves the small intestine, producing lesions similar to those seen in human acute small intestinal dysentery. Previous work established that, for a rapidly fatal infection to occur, animals had to be pretreated by starvation or by administration of carbon tetrachloride, and, after oral challenge with\n S. flexneri<\/jats:italic>\n , had to receive opium. Data are presented indicating that, in the guinea pig, the motility of the small intestine is a major defense mechanism in clearing bacteria from the gut. It is concluded that the two modes of pretreatment potentiate the ability of opium to decrease this motility, and hence increase susceptibility to enteric infection.\n <\/jats:p>","DOI":"10.1128\/jb.85.1.119-125.1963","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T21:24:49Z","timestamp":1578086689000},"page":"119-125","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["EXPERIMENTAL\n SHIGELLA<\/i>\n INFECTIONS VI"],"prefix":"10.1128","volume":"85","author":[{"given":"Samuel B.","family":"Formal","sequence":"first","affiliation":[{"name":"Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald D.","family":"Abrams","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman","family":"Schneider","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmuth","family":"Sprinz","sequence":"additional","affiliation":[{"name":"Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/JB.46.1.1-13.1943","article-title":"The intestinal flora of the guinea pig","volume":"46","author":"CRECELIUS H. G.","year":"1943","unstructured":"CRECELIUS , H. G. , AND L. F. RETTGER. 1943 . The intestinal flora of the guinea pig . J. Bacteriol. 46 : 1 - 13 .","journal-title":"J. Bacteriol."},{"key":"p_2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.1700790116","article-title":"The fate of bacteria in the small intestine","volume":"79","author":"DIXON J. M.","year":"1960","unstructured":"DIXON , J. M. S. 1960 . The fate of bacteria in the small intestine . J. Pathol. Bacteriol. 79 : 131 - 140 .","journal-title":"J. Pathol. Bacteriol."},{"key":"p_3","unstructured":"FORMAL S. B. G. J. DAMMIN E. H. LABREC AND H. SCHNEIDER. 1958. Experimental Shigella infections: characteristics of a fatal"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.85.1.119-125.1963","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.85.1.119-125.1963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:11:09Z","timestamp":1627578669000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.85.1.119-125.1963"}},"subtitle":["Role of the Small Intestine in an Experimental Infection in Guinea Pigs"],"short-title":[],"issued":{"date-parts":[[1963,1]]},"references-count":3,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1963,1]]}},"alternative-id":["10.1128\/jb.85.1.119-125.1963"],"URL":"https:\/\/doi.org\/10.1128\/jb.85.1.119-125.1963","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,1]]},"assertion":[{"value":"2021-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}