{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:30:07Z","timestamp":1785475807265,"version":"3.56.0"},"reference-count":6,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1964,1,1]],"date-time":"1964-01-01T00:00:00Z","timestamp":-189388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1964,1]]},"abstract":"<jats:p>\n            <jats:sc>Converse, John<\/jats:sc>\n            L. (U.S. Army Biological Laboratories, Fort Detrick, Frederick, Md.),\n            <jats:sc>Steven P. Pakes, Ernest M. Snyder, and Merida W. Castleberry<\/jats:sc>\n            . Experimental primary cutaneous coccidioidomycosis in the monkey. J. Bacteriol.\n            <jats:bold>87:<\/jats:bold>\n            81\u201385. 1964.\u2014Primary cutaneous coccidioidomycosis was studied in the monkey (\n            <jats:italic>Macaca mulatta<\/jats:italic>\n            ) to find a suitable strain of\n            <jats:italic>Coccidioides immitis<\/jats:italic>\n            for use as a viable vaccine. Intradermal inoculation (medial surface of the right forearm) produced more severe vaccination reactions (draining vaccination site and axillary lymph node hypertrophy) than did subcutaneous injection. A subcutaneous vaccine dose of 10 arthrospores resulted in less reaction than a 100-spore dose. Moreover, dissemination beyond the regional lymph nodes did not occur after injection of ten spores of even the most virulent strains of\n            <jats:italic>C. immitis<\/jats:italic>\n            . Two of the five strains tested (Silveira, M-11, D-76, Cash, and a colonial isolate from Cash designated CW1) exhibited very mild vaccination reactions and appeared to have been cleared from the tissues upon necropsy at 10 months postvaccination. These two strains (Cash and CW1) appear promising for further immunological studies with a viable vaccine.\n          <\/jats:p>","DOI":"10.1128\/jb.87.1.81-85.1964","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T21:28:26Z","timestamp":1578086906000},"page":"81-85","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["EXPERIMENTAL PRIMARY CUTANEOUS COCCIDIOIDOMYCOSIS IN THE MONKEY"],"prefix":"10.1128","volume":"87","author":[{"given":"John L.","family":"Converse","sequence":"first","affiliation":[{"name":"U.S. Army Biological Laboratories, Fort Detrick, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Pakes","sequence":"additional","affiliation":[{"name":"U.S. Army Biological Laboratories, Fort Detrick, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest M.","family":"Snyder","sequence":"additional","affiliation":[{"name":"U.S. Army Biological Laboratories, Fort Detrick, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merida W.","family":"Castleberry","sequence":"additional","affiliation":[{"name":"U.S. Army Biological Laboratories, Fort Detrick, Frederick, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"p_1","unstructured":"CONVERSE J. L. M. W. CASTLEBERRY AND E. M. SNYDER. 1961. A viable prophylactic vaccine against coccidioidomycosis in monkeys. Trans. 6th Annual Meeting Veterans Administration-Armed Forces Coccidioidomycosis Coop Study Los Angeles Calif. p. 26."},{"key":"p_2","unstructured":"COCCIDIOIDOMYCOSIS COOP STUDY. 1961. Discussion from the floor. Trans. 6th Annual Meeting Veterans Administration-Armed Forces Coccidioidomycosis Coop Study Los Angeles Calif. p. 29."},{"key":"p_3","first-page":"596","article-title":"Granuloma coccidioides","volume":"14","author":"GUY W. H.","year":"1926","unstructured":"GUY , W. H. , AND F. M. JACOB. 1926 . Granuloma coccidioides . Arch. Dermatol. Syphilol. 14 : 596 .","journal-title":"Arch. Dermatol. Syphilol."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/infdis\/79.1.12","article-title":"Studies with Coccidioides immitis; submerged growth in liquid mediums","volume":"79","author":"ROESSLER W. G.","year":"1946","unstructured":"ROESSLER , W. G. , E. J. HERBST , W. G. MCCULLOUGH , R. C. MILLS , A ND C . R. BREWER. 1946 . Studies with Coccidioides immitis; submerged growth in liquid mediums . J. Infect. Diseases 79 : 12 - 22 .","journal-title":"J. Infect. Diseases"},{"key":"p_5","first-page":"3","article-title":"The Public Health significance of coccidioidomycosis","volume":"575","author":"SMITH C. E.","year":"1957","unstructured":"SMITH , C. E. , D. PAPPAGIANIS , A ND M . SAITO. 1957 . The Public Health significance of coccidioidomycosis . Public Health Serv. Publ. 575 : 3 - 9 .","journal-title":"Public Health Serv. Publ."},{"key":"p_6","first-page":"233","article-title":"Primary cutaneous coccidioidomycosis; the criteria for diagnosis and a report of a case","volume":"79","author":"WILSON J. W.","year":"1953","unstructured":"WILSON , J. W. , C. E. SMITH , AND 0. A. PLUNKETT. 1953 . Primary cutaneous coccidioidomycosis; the criteria for diagnosis and a report of a case . Calif. Med 79 : 233 - 239 .","journal-title":"Calif. Med"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.87.1.81-85.1964","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.87.1.81-85.1964","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:25:11Z","timestamp":1630715111000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.87.1.81-85.1964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1964,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1964,1]]}},"alternative-id":["10.1128\/jb.87.1.81-85.1964"],"URL":"https:\/\/doi.org\/10.1128\/jb.87.1.81-85.1964","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[1964,1]]},"assertion":[{"value":"2021-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}