{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T19:41:03Z","timestamp":1700768463606},"reference-count":15,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1964,3,1]],"date-time":"1964-03-01T00:00:00Z","timestamp":-184204800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1964,3]]},"abstract":"<jats:p><jats:sc>Harmon, Shirley<\/jats:sc>A. (Ohio State University, Columbus),<jats:sc>and Jack N. Baldwin<\/jats:sc>. Nature of the determinant controlling penicillinase production in<jats:italic>Staphylococcus aureus<\/jats:italic>. J. Bacteriol.<jats:bold>87:<\/jats:bold>593\u2013597. 1964.\u2014From three penicillinase-producing strains of<jats:italic>Staphylococcus aureus<\/jats:italic>38 penicillin-sensitive mutants were isolated. With phages 80 and 53 of the International Typing Series, each of these mutants was a competent recipient of the penicillinase marker from the parent strains. Although numerous reciprocal transductions were performed between penicillin-sensitive mutants, no penicillinase-producing recombinants were observed. Reversion of the penicillinase-negative mutants to capacity to produce penicillinase was never observed. When tested for 50 distinctive physiological characteristics, the mutants generally were similar to the parent strains except for resistance to penicillin. One penicillin-sensitive mutant failed to produce detectable amounts of five exoenzymes. By treating resistant strains with acridine orange, it was possible to isolate sensitive strains at a frequency that was 60 times greater than the spontaneous mutation rate. Thus, the determinant controlling the capacity of strains of<jats:italic>S. aureus<\/jats:italic>to produce penicillinase appears to be a cytoplasmic element.<\/jats:p>","DOI":"10.1128\/jb.87.3.593-597.1964","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T21:29:02Z","timestamp":1578086942000},"page":"593-597","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["NATURE OF THE DETERMINANT CONTROLLING PENICILLINASE PRODUCTION IN<i>STAPHYLOCOCCUS AUREUS<\/i>"],"prefix":"10.1128","volume":"87","author":[{"given":"Shirley A.","family":"Harmon","sequence":"first","affiliation":[{"name":"Department of Microbiology, Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack N.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/path.1700590304","article-title":"Coagulase-positive staphylococci resistant to penicillin","volume":"59","author":"BARBER M.","year":"1947","unstructured":"BARBER , M. 1947 . Coagulase-positive staphylococci resistant to penicillin . J. Pathol. Bacteriol. 59 : 373 - 384 .","journal-title":"J. Pathol. Bacteriol."},{"key":"p_2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1099\/00221287-3-2-274","article-title":"The incidence of penicillin-sensitive variant colonies in penicillinase-producing strains of Staphylococcus pyogenes","volume":"3","author":"BARBER M.","year":"1949","unstructured":"BARBER , M. 1949 . The incidence of penicillin-sensitive variant colonies in penicillinase-producing strains of Staphylococcus pyogenes . J. Gen. Microbiol. 3 : 274 - 281 .","journal-title":"J. Gen. Microbiol."},{"key":"p_3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4049\/jimmunol.52.3.281","article-title":"The action of penicillin on staphylocccci","volume":"52","author":"BLAIR J. E.","year":"1946","unstructured":"BLAIR , J. E. , M. CARR , A ND J . BUCHMAN. 1946 . The action of penicillin on staphylocccci . J. Immunol. 52 : 281 - 292 .","journal-title":"J. Immunol."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1073\/pnas.46.1.57","article-title":"The effect of acridine dyes on mating type in Escherichia coli","author":"HIROTA Y.","year":"1960","unstructured":"HIROTA , Y. 1960 . The effect of acridine dyes on mating type in Escherichia coli . Proc. Natl. Acad. Sci. U. S. 46: 57 - 64 .","journal-title":"Proc. Natl. Acad. Sci. U."},{"key":"p_5","unstructured":"HUMBERT R. D. AND J. N. BALDWIN. 1963. An analysis of the methionine loci in Staphylococcus aureus. Bacteriol. Proc. p. 31."},{"key":"p_6","unstructured":"JACOB F. AND E. L. WOLLMAN. 1961. Sexuality and the genetics of bacteria. Academic Press Inc. New York."},{"key":"p_7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1126\/science.99.2579.452","article-title":"Extraction of a highly potent penicillin-inactivator from penicillinresistant staphylococci","volume":"99","author":"KIRBY W. 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