{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T07:54:05Z","timestamp":1693382045812},"reference-count":16,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1965,8,1]],"date-time":"1965-08-01T00:00:00Z","timestamp":-139449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1965,8]]},"abstract":"<jats:p>\n            <jats:sc>Carbonell, Luis<\/jats:sc>\n            M. (Instituto Venezolano de Investigaciones Cient\u00edficas, Caracas, Venezuela),\n            <jats:sc>and Joaqu\u00edn Rodr\u00edguez<\/jats:sc>\n            . Transformation of mycelial and yeast forms of\n            <jats:italic>Paracoccidioides brasiliensis<\/jats:italic>\n            in cultures and in experimental inoculations. J. Bacteriol.\n            <jats:bold>90:<\/jats:bold>\n            504\u2013510. 1965.\u2014Experimental transformations of mycelial to yeast and yeast to mycelial forms in culture, and mycelial to yeast forms in tissue, were studied. All the transitional forms that appeared in culture were also seen in tissue, but in fewer number. Most of the hyphae in culture were transformed into yeast, but only a few in tissue. Yeast appeared in testicle around the 3rd day after inoculation, but on the 10th day in subcutaneous tissue. Pathogenicity of mycelium was high, since yeast was found in almost all of the organs inoculated with mycelium. Histologically, an acute inflammation occurred first, owing to the inoculation of mycelium, followed by a giant-cell granuloma with abundant hyphae detritus. These giant cells almost disappeared about 10 days after inoculation, giving place to a second giant-cell granuloma with yeast forms.\n          <\/jats:p>","DOI":"10.1128\/jb.90.2.504-510.1965","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T21:36:33Z","timestamp":1578087393000},"page":"504-510","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":36,"title":["Transformation of Mycelial and Yeast Forms of\n            <i>Paracoccidioides brasiliensis<\/i>\n            in Cultures and in Experimental Inoculations"],"prefix":"10.1128","volume":"90","author":[{"given":"Luis M.","family":"Carbonell","sequence":"first","affiliation":[{"name":"Departamento de Patolog\u00eda Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Departamento de Patolog\u00eda Experimental, Instituto Venezolano de Investigaciones Cient\u00edficas Caracas, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/infdis\/63.3.324","article-title":"Comparison of infections of mice by mycelial and yeast forms of Blastomyces dermatitidis","volume":"63","author":"BAKER R.","year":"1938","unstructured":"BAKER , R. 1938 . Comparison of infections of mice by mycelial and yeast forms of Blastomyces dermatitidis . J. Infect. Diseases 63 : 324 - 329 .","journal-title":"J. Infect. Diseases"},{"key":"p_2","first-page":"321","article-title":"Contribugao ao conhecimiento da morfologia do agente da molestia de Lutz em seu ciclo parasitario. Primeira nota","volume":"5","author":"BOGLIOLO L.","year":"1945","unstructured":"BOGLIOLO , L. 1945 . Contribugao ao conhecimiento da morfologia do agente da molestia de Lutz em seu ciclo parasitario. Primeira nota . Rev. Brasil. Biol. 5 : 321 - 338 .","journal-title":"Rev. Brasil. Biol."},{"key":"p_3","first-page":"181","article-title":"Tercera contribugao ao conhecimiento da morfologia do agente da molestia de Lutz nos tecidos humanos parasitados","volume":"6","author":"BOGLIOLO L.","year":"1946","unstructured":"BOGLIOLO , L. 1946 . Tercera contribugao ao conhecimiento da morfologia do agente da molestia de Lutz nos tecidos humanos parasitados . Rev. Brasil. Biol. 6 : 181 - 197 .","journal-title":"Rev. Brasil. Biol."},{"key":"p_4","unstructured":"BORELLI D. 1955. Las aleurfas del Paracoccidioides brasiliensis. Mem. VI Congr. Venezolano Ciencias Med. p. 2241-2253. J. BACTERIOL."},{"key":"p_5","first-page":"130","article-title":"Hip 6tesis sobre ecologfa del","volume":"3","author":"BORELLI D.","year":"1962","unstructured":"BORELLI , D. 1962 . Hip 6tesis sobre ecologfa del Paracoccidioides. Dermatol. Venezolana 3 : 130 - 132 .","journal-title":"Paracoccidioides. Dermatol. Venezolana"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/12.6.413","article-title":"Cytochemistry of Paracoccidioides brasiliensis. I. Cytochemistry of cytoplasmic polysaccharides in yeast form cultures with light microscope","volume":"12","author":"CARBONELL L. M.","year":"1964","unstructured":"CARBONELL , L. M. , H. CASTEJ 6 N , AND L. POLLAK. 1964 . Cytochemistry of Paracoccidioides brasiliensis. I. Cytochemistry of cytoplasmic polysaccharides in yeast form cultures with light microscope . J. Histochem. Cytochem. 12 : 413 - 418 .","journal-title":"J. Histochem. Cytochem."},{"key":"p_7","first-page":"396","article-title":"Phase levure et phase filamenteuse de Paracoccidioides brasiliensis: etude des noyaux","volume":"87","author":"DROUHET E.","year":"1954","unstructured":"DROUHET , E. , AND R. C. ZAPATER. 1954 . Phase levure et phase filamenteuse de Paracoccidioides brasiliensis: etude des noyaux . Ann. Inst. Pasteur 87 : 396 - 403 .","journal-title":"Ann. Inst. Pasteur"},{"key":"p_8","first-page":"192","article-title":"Experimental South American Blastomycosis of the guinea pig. An inmunologic and pathologic study","volume":"24","author":"FAVA NETTO C., T.","year":"1961","unstructured":"FAVA NETTO , C., T. BRITO , A ND C . DA SILVA LACAZ . 1961 . Experimental South American Blastomycosis of the guinea pig. An inmunologic and pathologic study . Pathol. 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