{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:15:43Z","timestamp":1769818543144,"version":"3.49.0"},"reference-count":15,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1966,2,1]],"date-time":"1966-02-01T00:00:00Z","timestamp":-123552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1966,2]]},"abstract":"<jats:p>\n            <jats:sc>Selye, H.<\/jats:sc>\n            (Universit\u00e9 de Montr\u00e9al, Montreal, Canada),\n            <jats:sc>B. Tuchweber, and L. Bert\u00f3k<\/jats:sc>\n            . Effect of lead acetate on susceptibility of rats to bacterial endotoxins. J. Bacteriol.\n            <jats:bold>91:<\/jats:bold>\n            884\u2013890. 1966.\u2014A single, normally well-tolerated, intravenous injection of lead acetate increases the sensitivity of the rat to the endotoxins of various gram-negative bacteria about 100,000 times above normal. Under the conditions of these experiments, the mortality and organ changes normally produced by the intravenous injection of 100 \u03bcg of\n            <jats:italic>Escherichia coli<\/jats:italic>\n            endotoxin were essentially the same as those obtained by use of 1 nanogram in lead-sensitized rats. The sensitizing effect of lead acetate for\n            <jats:italic>E. coli<\/jats:italic>\n            endotoxin is greatest when the two agents are given simultaneously. However, considerable sensitization is still detectable when endotoxin is injected up to 1 hr before or 7 hr after sensitization with lead. No sensitization was noted when the endotoxin was administered 24 hr before or after lead acetate. Under our experimental conditions, the minimal dose of lead acetate which could still induce significant sensitization to\n            <jats:italic>E. coli<\/jats:italic>\n            endotoxin was 1 mg per 100 g of body weight. Although lead acetate induces a high degree of susceptibility to various endotoxins, other reticuloendothelial blocking agents did not acquire unusual toxicity after pretreatment with lead. Finally, none of the other metals or reticuloendothelial blocking agents tested could duplicate the pronounced decrease in endotoxin resistance induced by lead acetate.\n          <\/jats:p>","DOI":"10.1128\/jb.91.2.884-890.1966","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T01:51:19Z","timestamp":1578189079000},"page":"884-890","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":144,"title":["Effect of Lead Acetate on the Susceptibility of Rats to Bacterial Endotoxins"],"prefix":"10.1128","volume":"91","author":[{"given":"H.","family":"Selye","sequence":"first","affiliation":[{"name":"Institut de M\u00e9decine et de Chirurgie Exp\u00e9rimentales, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tuchweber","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine et de Chirurgie Exp\u00e9rimentales, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bertok","sequence":"additional","affiliation":[{"name":"Institut de M\u00e9decine et de Chirurgie Exp\u00e9rimentales, Universit\u00e9 de Montr\u00e9al, Montreal, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","first-page":"908","article-title":"Uber die Einflusse der Nebennierenexstirpation auf das Diphtherietoxin","volume":"53","author":"AIBA Y.","year":"1941","unstructured":"AIBA , Y. 1941 . Uber die Einflusse der Nebennierenexstirpation auf das Diphtherietoxin . Okayama Igakkai Zasshi 53 : 908 - 909 .","journal-title":"Okayama Igakkai Zasshi"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3181\/00379727-64-15728","article-title":"Effect of reticulo-endothelial blockade on immunity to the Shwartzman phenomenon","volume":"64","author":"BEESON P. B.","year":"1947","unstructured":"BEESON , P. B. 1947 . Effect of reticulo-endothelial blockade on immunity to the Shwartzman phenomenon . Proc. Soc. Exptl. Biol. Med. 64 : 146 - 149 .","journal-title":"Proc. Soc. Exptl. Biol. Med."},{"key":"p_3","first-page":"1669","article-title":"Sur l'action d'une hormone corticosurr 6nale preparee par voie de synthese (ac 6tate de 11-dehydrocorcosterone) chez des animaux traites par une endotoxine bacterienne","volume":"224","author":"DELAUNAY A.","year":"1947","unstructured":"DELAUNAY , A. , AND J. LEBRUN. 1947 . Sur l'action d'une hormone corticosurr 6nale preparee par voie de synthese (ac 6tate de 11-dehydrocorcosterone) chez des animaux traites par une endotoxine bacterienne . Compt. Rend. Soc. Biol. 224 : 1669 - 1670 .","journal-title":"Compt. Rend. Soc. Biol."},{"key":"p_4","first-page":"625","article-title":"Studies on the generalized Shwartzman reaction. Il. The production of bilateral cortical necrosis of the kidneys by a single injection of bacterial toxin in rabbits previously treated with Thorotrast or trypan blue","volume":"96","author":"GOOD R. A.","year":"1952","unstructured":"GOOD , R. A. , AND L. THOMAS. 1952 . Studies on the generalized Shwartzman reaction. Il. The production of bilateral cortical necrosis of the kidneys by a single injection of bacterial toxin in rabbits previously treated with Thorotrast or trypan blue . J. Exptl. Med. 96 : 625 - 641 .","journal-title":"J. Exptl. 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A.","year":"1946","unstructured":"LEWIS , L. A. , AND I. H. PAGE. 1946 . Method of assaying steroids and adrenal extracts for protective action against toxic material (typhoid vaccine) . J. Lab. Clin. Med. 31 : 1325 - 1329 .","journal-title":"J. Lab. Clin. Med."},{"key":"p_8","unstructured":"McKAY D. G. 1965. Disseminated intravascular coagulation. An intermediary mechanism of disease. Hoeber Medical Division Harper & Row Publishers Inc. New York."},{"key":"p_9","doi-asserted-by":"crossref","first-page":"648","DOI":"10.3181\/00379727-28-5466","article-title":"Immunological studies in relation to suprarenal gland. VII. Effect of bilateral suprarenalectomy on acquired resistance in rats","volume":"28","author":"MARMORSTON-GOT SMAN","year":"1931","unstructured":"MARMORSTON-GOT rE SMAN , J., AND D. PERLA. 1931 . Immunological studies in relation to suprarenal gland. VII. Effect of bilateral suprarenalectomy on acquired resistance in rats . Proc. Soc. Exptl. Biol. Med. 28 : 648 - 650 .","journal-title":"Proc. Soc. Exptl. Biol. Med."},{"key":"p_10","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3181\/00379727-28-5374","article-title":"Injections of cortin on resistance of suprarenalectomized rats. Biological assay of extracts of suprarenal cortex","volume":"28","author":"PERLA D.","year":"1931","unstructured":"PERLA , D. , AND J. MARMORSTON-GOTTESMAN . 1931 . Injections of cortin on resistance of suprarenalectomized rats. Biological assay of extracts of suprarenal cortex . Proc. Soc. Exptl. Biol. Med. 28 : 475 - 477 .","journal-title":"Proc. Soc. Exptl. Biol. Med."},{"key":"p_11","first-page":"806","article-title":"Pulmonary emboli in suprarenal insufficiency","volume":"2","author":"SCOTT W. J.","year":"1926","unstructured":"SCOTT , W. J. M., AND H. S. THATCHER. 1926 . Pulmonary emboli in suprarenal insufficiency . Arch. Pathol. Lab. Med. 2 : 806 - 814 .","journal-title":"Arch. Pathol. Lab. 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