{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:27:56Z","timestamp":1769516876724,"version":"3.49.0"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1966,10,1]],"date-time":"1966-10-01T00:00:00Z","timestamp":-102643200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1966,10]]},"abstract":"<jats:p>\n            <jats:sc>Youngner, Julius S<\/jats:sc>\n            . (University of Pittsburgh, Pittsburgh, Pa.),\n            <jats:sc>Anne W. Scott, Jules V. Hallum, and Warren R. Stinebring<\/jats:sc>\n            . Interferon production by inactivated Newcastle disease virus in cell cultures and in mice. J. Bacteriol.\n            <jats:bold>92:<\/jats:bold>\n            862\u2013868. 1966.\u2014A comparison was made of the effects of ultraviolet (UV) irradiation or heating at 56 C on the interferon-stimulating capacity of Newcastle disease virus in primary chick embryo fibroblast (CE) cultures, in L-cell cultures, and in the intact mouse. The data obtained indicated the critical importance of the host cell system used for interferon production. Virus inactivated by UV irradiation, as well as infective virus, was an effective stimulus of interferon production in L cells and in mice, and this property persisted on continued irradiation. In contrast, in CE cell cultures, infective virus produced no interferon, whereas UV-irradiated virus produced maximal interferon titers when all infectivity was destroyed; continued irradiation resulted in a rapid loss of the interferon-stimulating capacity of the virus. Virus inactivated at 56 C did not produce interferon in CE or L-cell cultures. In the intact mouse, on the other hand, heat-inactivated virus was capable of stimulating the release of significant levels of circulating interferon.\n          <\/jats:p>","DOI":"10.1128\/jb.92.4.862-868.1966","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T01:55:47Z","timestamp":1578189347000},"page":"862-868","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":94,"title":["Interferon Production by Inactivated Newcastle Disease Virus in Cell Cultures and in Mice"],"prefix":"10.1128","volume":"92","author":[{"given":"Julius S.","family":"Youngner","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne W.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules V.","family":"Hallum","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren R.","family":"Stinebring","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1126\/science.141.3585.1061","article-title":"Circulating interferon in mice after intravenous injection of virus","volume":"141","author":"BARON S.","year":"1963","unstructured":"BARON , S. , AND C. E. BUCKLER. 1963 . Circulating interferon in mice after intravenous injection of virus . Science 141 : 1061 - 1063 .","journal-title":"Science"},{"key":"p_2","first-page":"452","article-title":"Some factors affecting the production of interferon","volume":"39","author":"BURKE D. C.","year":"1958","unstructured":"BURKE , D. C. , AND A. ISAACS. 1958 . Some factors affecting the production of interferon . Brit. J. Exptl. Pathol. 39 : 452 - 458 .","journal-title":"Brit. J. Exptl. Pathol."},{"key":"p_3","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0042-6822(65)90124-8","article-title":"Interferon activity associated with high molecular weight proteins in the circulation of mice injected with endotoxin or bacteria","volume":"27","author":"HALLUM J. V.","year":"1965","unstructured":"HALLUM , J. V. , J. S. YOUNGNER , A ND W . R. STINEBRING. 1965 . Interferon activity associated with high molecular weight proteins in the circulation of mice injected with endotoxin or bacteria . Virology 27 : 429 - 431 .","journal-title":"Virology"},{"key":"p_4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1084\/jem.110.4.525","article-title":"Studies on persistent infections of tissue cultures. IV. Evidence for the production of an interferon in MCN cells by myxoviruses","volume":"110","author":"HENLE W., G.","year":"1959","unstructured":"HENLE , W., G. HENLE , F. DEINHARDT , A ND V . V. BERGS . 1959 . Studies on persistent infections of tissue cultures. IV. Evidence for the production of an interferon in MCN cells by myxoviruses . J. Exptl. Med. 110 : 525 - 541 .","journal-title":"J. Exptl. Med."},{"key":"p_5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0042-6822(65)90052-8","article-title":"Metabolic determinants of interferon formation","volume":"25","author":"M. K.","year":"1965","unstructured":"Ho, M., AND M. K. BREINIG. 1965 . Metabolic determinants of interferon formation . Virology 25 : 331 - 339 .","journal-title":"Virology"},{"key":"p_6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2307\/3570988","article-title":"A small and inexpensive ultraviolet dose-rate meter useful in biological experiments","volume":"14","author":"JAGGER J.","year":"1961","unstructured":"JAGGER , J. 1961 . A small and inexpensive ultraviolet dose-rate meter useful in biological experiments . Radiation Res. 14 : 394 - 403 .","journal-title":"Radiation Res."},{"key":"p_7","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.145.3634.811-a","article-title":"Purified interferons. Physical properties and species specificity","volume":"145","author":"MERIGAN T. C.","year":"1964","unstructured":"MERIGAN , T. C. 1964 . Purified interferons. Physical properties and species specificity . Science 145 : 811 - 813 .","journal-title":"Science"},{"key":"p_8","first-page":"301","article-title":"Quantitative studies on viral interference in suspended L cells. I. Growth characteristics and interfering activities of vesicular stomatitis, Newcastle disease, and influenza A viruses","volume":"17","author":"PAUKER K., Z.","year":"1962","unstructured":"PAUKER , K., Z. SKURSKA , A ND W . HENLE. 1962 . Quantitative studies on viral interference in suspended L cells. I. Growth characteristics and interfering activities of vesicular stomatitis, Newcastle disease, and influenza A viruses . Virology 17 : 301 - 331 1.","journal-title":"Virology"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/204712a0","article-title":"Patterns of interferon appearance in mice injected with bacteria or bacterial endotoxin","volume":"204","author":"STINEBRING W. R.","year":"1964","unstructured":"STINEBRING , W. R. , AND J. S. YOUNGNER. 1964 . Patterns of interferon appearance in mice injected with bacteria or bacterial endotoxin . Nature 204 : 712 .","journal-title":"Nature"},{"key":"p_10","first-page":"323","article-title":"Biological studies of interferon. I. Suppression of cellular infection with Eastern equine encephalomyelitis virus","volume":"13","author":"WAGNER R. R.","year":"1961","unstructured":"WAGNER , R. R. 1961 . Biological studies of interferon. I. Suppression of cellular infection with Eastern equine encephalomyelitis virus . Virology 13 : 323 - 337 .","journal-title":"Virology"},{"key":"p_11","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/0042-6822(65)90179-0","article-title":"Influence of inhibitors of protein synthesis on interferon formation in mice","volume":"27","author":"YOUNGNER J. S.","year":"1965","unstructured":"YOUNGNER , J. S. , W. R. STINEBRING , A ND S . E. TAUBE. 1965 . Influence of inhibitors of protein synthesis on interferon formation in mice . Virology 27 : 541 - 550 .","journal-title":"Virology"}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.92.4.862-868.1966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.92.4.862-868.1966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:22:43Z","timestamp":1627579363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.92.4.862-868.1966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1966,10]]}},"alternative-id":["10.1128\/jb.92.4.862-868.1966"],"URL":"https:\/\/doi.org\/10.1128\/jb.92.4.862-868.1966","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,10]]},"assertion":[{"value":"2021-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}