{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T09:53:15Z","timestamp":1695635595081},"reference-count":15,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1967,1,1]],"date-time":"1967-01-01T00:00:00Z","timestamp":-94694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1967,1]]},"abstract":"<jats:p>Hyperimmune sera against spherules and against arthrospores of<jats:italic>Coccidioides immitis<\/jats:italic>were prepared by inoculation of rabbits. The antibody content of these sera was studied by the agar gel diffusion method. It was observed that antispherule pooled sera formed multiple precipitin bands with extracts of spherules and of arthrospores. The antiarthrospore pooled serum, however, failed to precipitate with the spherule extract, and formed a single band in the presence of an arthrospore solution. When the spherule and the arthrospore extracts were tested with a variety of different antisera, it was observed that the spherule preparation formed bands only in combination with anti-purified spherule pooled serum, whereas the arthrospore extract precipitated with anti-purified spherule, antiarthrospore, and anti-<jats:italic>Histoplasma capsulatum<\/jats:italic>pooled sera. It was also observed that a spherule culture supernatant solution formed five precipitin bands in combination with anti-spherule pooled sera, formed one band with pooled antiserum from rabbits with coccidioidomycosis, and did not precipitate in the presence of antiarthrospore pooled serum. Coccidioidin, however, formed two bands in the presence of any of these antisera. It was therefore concluded that extracts from the spherule phase of<jats:italic>C. immitis<\/jats:italic>differed from solutions obtained from the arthrospore and mycelial phases.<\/jats:p>","DOI":"10.1128\/jb.93.1.1-6.1967","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T01:57:30Z","timestamp":1578189450000},"page":"1-6","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Serological Comparison of the Three Morphological Phases of<i>Coccidioides immitis<\/i>by the Agar Gel Diffusion Method"],"prefix":"10.1128","volume":"93","author":[{"given":"Marshall E.","family":"Landay","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina"},{"name":"Department of the Army, Fort Detrick, Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Wheat","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina"},{"name":"Department of the Army, Fort Detrick, Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman F.","family":"Conant","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina"},{"name":"Department of the Army, Fort Detrick, Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin P.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Duke University Medical Center, Durham, North Carolina"},{"name":"Department of the Army, Fort Detrick, Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1083\/jcb.9.3.627","article-title":"Electron microscopy of cultured spherules of Coccidioides immitis","volume":"9","author":"BRESLAU A. M.","year":"1961","unstructured":"BRESLAU , A. M. , T. J. HENSLEY , A ND J . 0. ERICKSON. 1961 . Electron microscopy of cultured spherules of Coccidioides immitis . J. Biophys. Biochem. Cytol. 9 : 627 - 637 .","journal-title":"J. Biophys. Biochem. Cytol."},{"key":"p_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1749-6632.1960.tb20139.x","article-title":"The accuracy of serologic methods in diagnosis","volume":"89","author":"CAMPBELL C. C.","year":"1960","unstructured":"CAMPBELL , C. C. 1960 . The accuracy of serologic methods in diagnosis . Ann. N. Y. Acad. Sci. 89 : 163 - 177 .","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"p_3","first-page":"896","article-title":"Serologic diagnosis with respect to histoplasmosis, coccidioidomycosis, and blastomycosis and the problems of cross reactions","volume":"42","author":"CAMPBELL C. C.","year":"1953","unstructured":"CAMPBELL , C. C. , AND G. E. BINKLEY. 1953 . Serologic diagnosis with respect to histoplasmosis, coccidioidomycosis, and blastomycosis and the problems of cross reactions . J. Lab. Clin. Med. 42 : 896 - 906 .","journal-title":"J. Lab. Clin. Med."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1128\/jb.74.1.106-107.1957","article-title":"Effect of surface active agents on endosporulation of Coccidioides immitis in a chemically defined medium","volume":"74","author":"CONVERSE J. L.","year":"1957","unstructured":"CONVERSE , J. L. 1957 . Effect of surface active agents on endosporulation of Coccidioides immitis in a chemically defined medium . J. Bacteriol. 74 : 106 - 107 .","journal-title":"J. Bacteriol."},{"key":"p_5","first-page":"255","article-title":"A further evaluation of histoplasmin and yeast phase antigen of Histoplasma capsulatum in the complement fixation test","volume":"48","author":"HILL G. B.","year":"1956","unstructured":"HILL , G. B. , AND C. C. CAMPBELL. 1956 . A further evaluation of histoplasmin and yeast phase antigen of Histoplasma capsulatum in the complement fixation test . J. Lab. Clin. Med. 48 : 255 - 263 .","journal-title":"J. Lab. Clin. Med."},{"key":"p_6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/00362176385190441","article-title":"Immunodiffusion as a screening test for coccidioidomycosis serology","volume":"2","author":"HUPPERT M.","year":"1963","unstructured":"HUPPERT , M. , AND J. W. BAILEY. 1963 . Immunodiffusion as a screening test for coccidioidomycosis serology . Sabouraudia 2 : 284 - 291 .","journal-title":"Sabouraudia"},{"key":"p_7","first-page":"112","article-title":"Purification of the spheruleendospore phase of Coccidioides immitis","volume":"1","author":"LE INE","year":"1961","unstructured":"LE v INE , H. B. 1961 . Purification of the spheruleendospore phase of Coccidioides immitis . 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