{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:16:44Z","timestamp":1778923004843,"version":"3.51.4"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[1967,1,1]],"date-time":"1967-01-01T00:00:00Z","timestamp":-94694400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1967,1]]},"abstract":"<jats:p>\n            <jats:italic>Bacillus megaterium<\/jats:italic>\n            ATCC 19213 secretes a cell division-initiating \u201cschizokinen\u201d (SK) which accumulates during its culture cycle to a concentration inversely proportional to the iron added to a sucrose-mineral salts medium. Secreted SK was purified from culture filtrates as a red Fe (III) chelate, and a fraction with similar biological properties was obtained from whole cells. Infrared spectra of SK, and analyses of unhydrolyzed and acid-hydrolyzed preparations indicated it to be a secondary hydroxamate; visible absorption maxima of the ferric complex showed\n            <jats:italic>p<\/jats:italic>\n            H dependency typical of ferric monohydroxamates. Schizokinen preparations from cultures grown at \u201cnormal\u201d and at low Fe concentrations were similar biologically and in certain of their chemical properties, but their\n            <jats:italic>\n              R\n              <jats:sub>F<\/jats:sub>\n            <\/jats:italic>\n            values and infrared spectra suggested nonidentity. Significant lag reduction of\n            <jats:italic>B. megaterium<\/jats:italic>\n            was effected by 0.2 m\u03bcg of SK per ml; the Fe (III)-SK chelate and \u201ciron-free\u201d SK were equally effective. A 50-m\u03bcg amount produced half-maximal growth response of the siderochrome auxotroph,\n            <jats:italic>Arthrobacter<\/jats:italic>\n            JG-9. Schizokinen also overcame ferrimycin A inhibition of three\n            <jats:italic>Bacillus<\/jats:italic>\n            species. These properties relate the\n            <jats:italic>B. megaterium<\/jats:italic>\n            schizokinen to the trihydroxamate siderochromes, although SK appears to be a monohydroxamate.\n          <\/jats:p>","DOI":"10.1128\/jb.93.1.286-294.1967","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T01:58:52Z","timestamp":1578189532000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Iron-chelating Hydroxamic Acid (Schizokinen) Active in Initiation of Cell Division in\n            <i>Bacillus megaterium<\/i>"],"prefix":"10.1128","volume":"93","author":[{"given":"B. R.","family":"Byers","sequence":"first","affiliation":[{"name":"Department of Microbiology, The University of Texas, Austin, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. V.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Texas, Austin, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. E.","family":"Lankford","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The University of Texas, Austin, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/hlca.19600430731","article-title":"Stoffwechselprodukte von Actinomyceten, 23 Mitteilung: Uber die Isolierung und Charakterisierung der Ferrioxamine A-F, neuer Wuchstoffe der Sideramin-Gruppe","volume":"43","author":"BICKEL H., R.","year":"1960","unstructured":"BICKEL , H., R. BOSSHARDT , E. GXUMANN , P. REUSSER , E. VISCHER , W. VOSER , A. WETTSTEIN , A ND H . ZAHNER. 1960 . 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