{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:13:30Z","timestamp":1761156810726},"reference-count":11,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[1967,9,1]],"date-time":"1967-09-01T00:00:00Z","timestamp":-73699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1967,9]]},"abstract":"<jats:p>\n            Differences in in vivo growth rates of\n            <jats:italic>Bacillus anthracis<\/jats:italic>\n            in the bodies of infected rats and guinea pigs showed the effect of innate species resistance. The effect of two levels of immunity imposed on these hosts demonstrated that, as the degree of immunity increased, the growth rate of organisms decreased and was accompanied by a decrease in terminal population. It was shown that growth rates in the blood best reflected the population growth in the entire host. Data obtained from the naturally resistant rat that had been immunized with both the Belton-Strange protective antigen and live vaccine demonstrated the role of \u201ctoxins\u201d in terminal anthrax. The in vivo morphological changes in anthrax bacilli pointed out errors regarding estimates of true terminal population of organisms when samples for counting were taken postmortem rather than at the time of death.\n          <\/jats:p>","DOI":"10.1128\/jb.94.3.600-608.1967","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T02:01:32Z","timestamp":1578189692000},"page":"600-608","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["In Vivo Growth and Distribution of Anthrax Bacilli in Resistant, Susceptible, and Immunized Hosts"],"prefix":"10.1128","volume":"94","author":[{"suffix":"Jr.","given":"William I.","family":"Jones","sequence":"first","affiliation":[{"name":"Process Development Division, Department of the Army, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Klein","sequence":"additional","affiliation":[{"name":"Process Development Division, Department of the Army, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry S.","family":"Walker","sequence":"additional","affiliation":[{"name":"Process Development Division, Department of the Army, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bill G.","family":"Mahlandt","sequence":"additional","affiliation":[{"name":"Process Development Division, Department of the Army, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James P.","family":"Dobbs","sequence":"additional","affiliation":[{"name":"Process Development Division, Department of the Army, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph E.","family":"Lincoln","sequence":"additional","affiliation":[{"name":"Process Development Division, Department of the Army, Fort Detrick, Frederick, Maryland 21701"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","first-page":"233","article-title":"Immunological studies of anthrax. I. An index to determine quantitative immunity","volume":"87","author":"DEARMON I. A.","year":"1961","unstructured":"DEARMON , I. A. , JR ., F. KLEIN , R. E. LINCOLN , B. G. MAHLANDT , A ND A . L. FERNELIUS. 1961 . Immunological studies of anthrax. I. An index to determine quantitative immunity . J. Immunol. 87 : 233 - 239 -","journal-title":"J. Immunol."},{"key":"p_2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1128\/jb.89.1.74-83.1965","article-title":"Quantitative assay for crude anthrax toxins","volume":"89","author":"HAINES B. W.","year":"1965","unstructured":"HAINES , B. W. , F. KLEIN , A ND R . E. LINCOLN. 1965 . Quantitative assay for crude anthrax toxins . J. Bacteriol. 89 : 74 - 83 .","journal-title":"J. Bacteriol."},{"key":"p_3","first-page":"477","article-title":"Studies on infection and immunity in anthrax. I. Enhancement of infection with B. anthracis by chicken yolks","volume":"11","author":"KAGA M.","year":"1956","unstructured":"KAGA , M. 1956 . Studies on infection and immunity in anthrax. I. Enhancement of infection with B. anthracis by chicken yolks . Japan. J. Bacteriol. 11 : 477 - 480 .","journal-title":"Japan. J. Bacteriol."},{"key":"p_4","first-page":"315","article-title":"The chemical basis of the virulence of Bacillus anthracis. III. The role of the terminal bacteremia in death of guinea pigs from anthrax","volume":"36","author":"KEPPIE J., H.","year":"1955","unstructured":"KEPPIE , J., H. SMITH , A ND P . W. HARRIS-SMITH . 1955 . The chemical basis of the virulence of Bacillus anthracis. III. The role of the terminal bacteremia in death of guinea pigs from anthrax . Brit. J. Exptl. Pathol. 36 : 315 - 322 .","journal-title":"Brit. J. Exptl. Pathol."},{"key":"p_5","first-page":"1021","article-title":"Immunization as a factor affecting the course of septicemic anthrax","volume":"133","author":"JONES ET AL LEIN","year":"1960","unstructured":"JONES ET AL . 5. K LEIN , F., B. G. MAHLANDT , R. E. LINCOLN , I. A. DEARMON , JR. , AND A. L. FERNELIUS. 1960 . Immunization as a factor affecting the course of septicemic anthrax . Science 133 : 1021 - 1022 .","journal-title":"Science"},{"key":"p_6","first-page":"15","article-title":"Immunological studies of anthrax. II. Levels of immunity against Bacillus anthracis obtained with protective antigen and live vaccine","volume":"88","author":"KLEIN F., I.","year":"1962","unstructured":"KLEIN , F., I. A. DEARMON , JR. , R. E. LINCOLN , B. G. MAHLANDT , A ND A . L. FERNELIUS. 1962 . Immunological studies of anthrax. II. Levels of immunity against Bacillus anthracis obtained with protective antigen and live vaccine . J. Immunol. 88 : 15 - 19 .","journal-title":"J. Immunol."},{"key":"p_7","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1128\/jb.85.5.1032-1038.1963","article-title":"Dual nature of resistance mechanisms as revealed by studies of anthrax septicemia","volume":"85","author":"KLEIN F., B.","year":"1963","unstructured":"KLEIN , F., B. W. HAINES , B. G. MAHLANDT , I. A. DEARMON , JR. , AND R. E. LINCOLN. 1963 . Dual nature of resistance mechanisms as revealed by studies of anthrax septicemia . J. Bacteriol. 85 : 1032 - 1038 .","journal-title":"J. Bacteriol."},{"key":"p_8","unstructured":"LINCOLN R. E. J. S. WALKER F. KLEIN AND"},{"key":"p_9","first-page":"727","article-title":"Immunologic studies of anthrax. IV. Evaluation of the immunogenicity of three components of anthrax toxin","volume":"96","author":"MAHLANDT B. G.","year":"1966","unstructured":"MAHLANDT , B. G. , F. KLEIN , R. E. LINCOLN , B. W. HAINES , W. I. JONES , JR. , AND R. H. FRIEDMAN. 1966 . Immunologic studies of anthrax. IV. Evaluation of the immunogenicity of three components of anthrax toxin . J. Immunol. 96 : 727 - 733 .","journal-title":"J. Immunol."},{"key":"p_10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/infdis\/112.2.187","article-title":"Changes in virulence of Bacillus anthracis spores affected by solids and challenge route","volume":"112","author":"RHIAN M. A.","year":"1962","unstructured":"RHIAN , M. A. , J. M. RILEY , V. L. WOLFE , A ND A . H. SIMMONS. 1962 . Changes in virulence of Bacillus anthracis spores affected by solids and challenge route . J. Infect. Diseases 112 : 187 - 193 .","journal-title":"J. Infect. Diseases"},{"key":"p_11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/infdis\/115.1.59","article-title":"Studies of anthrax infections in immunized guinea pigs","volume":"115","author":"WARD M. K.","year":"1965","unstructured":"WARD , M. K. , V. G. MCGANN , A. L. HOGGE , JR. , M. L. HUFF , R. G. KANODE , JR. , AND E. 0. ROBERTS. 1965 . Studies of anthrax infections in immunized guinea pigs . J. Infect. Diseases 115 : 59 - 67 .","journal-title":"J. Infect. 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