{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T14:16:05Z","timestamp":1756995365459},"reference-count":11,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[1967,10,1]],"date-time":"1967-10-01T00:00:00Z","timestamp":-71107200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1967,10]]},"abstract":"<jats:p>\n            Numerous reports have indicated that a single histoplasmin skin test may stimulate humoral antibodies to\n            <jats:italic>Histoplasma capsulatum<\/jats:italic>\n            antigens in histoplasmin-hypersensitive individuals. Although these investigations concur that antibody elevations are evoked, they vary in the reported degree of incidence and response induced, and they cast doubt on the interpretation of serological tests in the diagnosis of histoplasmosis. Histoplasmin-hypersensitive subjects (114) were bled prior to administration of the skin test, 2 days later, at the time this test was read, and 15 and 30 days after testing. No significant antibody titers were observed at 2 days. At 15- and 30-day intervals, only 17 (15%) of the subjects demonstrated circulating antibodies. All 17 showed agar gel bands; 5 demonstrated no complement-fixation (CF) titers, 10 produced CF antibodies ranging from 1:8 to 1:16, and 2 demonstrated titers of 1:32. The data suggest that skin testing does not interfere significantly with antibody levels in sera drawn approximately 2 days after administration of antigen. However, since titers as high as 1:32 were obtained at later intervals, such reactions should be evaluated cautiously and only after consideration of clinical findings.\n          <\/jats:p>","DOI":"10.1128\/jb.94.4.798-803.1967","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T02:02:24Z","timestamp":1578189744000},"page":"798-803","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":26,"title":["Effects of a Single Histoplasmin Skin Test on the Serological Diagnosis of Histoplasmosis"],"prefix":"10.1128","volume":"94","author":[{"given":"Leo","family":"Kaufman","sequence":"first","affiliation":[{"name":"Bureau of Disease Prevention and Environmental Control, National Communicable Disease Center, Public Health Service, Atlanta, Georgia 30333"},{"name":"Veterans Administration Hospital, Nashville, Tennessee 37203"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert T.","family":"Terry","sequence":"additional","affiliation":[{"name":"Bureau of Disease Prevention and Environmental Control, National Communicable Disease Center, Public Health Service, Atlanta, Georgia 30333"},{"name":"Veterans Administration Hospital, Nashville, Tennessee 37203"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Schubert","sequence":"additional","affiliation":[{"name":"Bureau of Disease Prevention and Environmental Control, National Communicable Disease Center, Public Health Service, Atlanta, Georgia 30333"},{"name":"Veterans Administration Hospital, Nashville, Tennessee 37203"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Bureau of Disease Prevention and Environmental Control, National Communicable Disease Center, Public Health Service, Atlanta, Georgia 30333"},{"name":"Veterans Administration Hospital, Nashville, Tennessee 37203"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","first-page":"927","article-title":"Further studies on the development of complementfixing antibodies and precipitins in healthy histoplasmin-sensitive persons following a single histoplasmin skin test","volume":"90","author":"CAMPBELL C. C.","year":"1964","unstructured":"CAMPBELL , C. C. , AND G. B. HILL. 1964 . Further studies on the development of complementfixing antibodies and precipitins in healthy histoplasmin-sensitive persons following a single histoplasmin skin test . Am. Rev. Respirat. Diseases 90 : 927 - 934 .","journal-title":"Am. Rev. Respirat. Diseases"},{"key":"p_2","first-page":"673","article-title":"Influence of skin-testing on the serologic diagnosis of tuberculosis and histoplasmosis","volume":"98","author":"HEINER D. C.","year":"1959","unstructured":"HEINER , D. C. 1959 . Influence of skin-testing on the serologic diagnosis of tuberculosis and histoplasmosis . Am. J. Diseases Children 98 : 673 - 674 .","journal-title":"Am. J. Diseases Children"},{"key":"p_3","first-page":"255","article-title":"A further evaluation of histoplasmin and yeast phase antigens of Histoplasma capsulatum in the complement fixation test","volume":"48","author":"HILL G. B.","year":"1956","unstructured":"HILL , G. B. , AND C. C. CAMPBELL. 1956 . A further evaluation of histoplasmin and yeast phase antigens of Histoplasma capsulatum in the complement fixation test . J. Lab. Clin. Med. 48 : 255 - 263 .","journal-title":"J. Lab. Clin. Med."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2307\/4592678","article-title":"Serology of systemic fungus diseases","volume":"81","author":"KAUFMAN L.","year":"1966","unstructured":"KAUFMAN , L. 1966 . Serology of systemic fungus diseases . Public Health Rept. (U.S.) 81 : 177 - 185 .","journal-title":"Public Health Rept. (U.S.)"},{"key":"p_5","first-page":"770","article-title":"The interpretation of agargel precipitin reactions in histoplasmosis","volume":"66","author":"KLITE P. D.","year":"1965","unstructured":"KLITE , P. D. 1965 . The interpretation of agargel precipitin reactions in histoplasmosis . J. Lab. Clin. Med. 66 : 770 - 787 .","journal-title":"J. Lab. Clin. Med."},{"key":"p_6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1093\/ajcp\/34.5.434","article-title":"The development of positive serologic tests with Histoplasma capsulatum antigens following single histoplasmin skin tests","volume":"34","author":"DEARMAN S. C.","year":"1960","unstructured":"Mc DEARMAN , S. C. , AND J. M. YOUNG. 1960 . The development of positive serologic tests with Histoplasma capsulatum antigens following single histoplasmin skin tests . Am. J. Clin. Pathol. 34 : 434 - 438 .","journal-title":"Am. J. Clin. Pathol."},{"key":"p_7","unstructured":"NICHOLAS W. M. J. A. WIER L. R. KUHN 803"},{"key":"p_8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1699-0463.1949.tb00751.x","article-title":"Antigen-antibody reactions in gels","volume":"26","author":"OUCHTERLONY","year":"1949","unstructured":"OUCHTERLONY , 0. 1949 . Antigen-antibody reactions in gels . Acta Pathol. Microbiol. Scand. 26 : 507 - 515 .","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"p_9","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1056\/NEJM196308222690803","article-title":"Effects of diagnostic skin-testing on antibody levels for histoplasmosis","volume":"269","author":"SIGRE T, M","year":"1963","unstructured":"SIGRE s T, M . L., F. L. LUMMUS , G. D. CAMPBELL , J. F. BusEy, AND F. ALLISON. 1963 . Effects of diagnostic skin-testing on antibody levels for histoplasmosis . New Engl. J. Med. 269 : 390 - 394 .","journal-title":"New Engl. J. Med."},{"key":"p_10","unstructured":"U.S. PUBLIC HEALTH SERVICE. 1965. Standardized diagnostic complement fixation method and adaptation to micro test. U.S. Public Health Serv. PubI. 1228."},{"key":"p_11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/jb.89.3.589-596.1965","article-title":"Relationship of histoplasmin agar gel bands and complement fixation titers in histoplasmosis","volume":"89","author":"WIGGINS G. L.","year":"1965","unstructured":". WIGGINS , G. L. , AND J. H. SCHUBERT. 1965 Relationship of histoplasmin agar gel bands and complement fixation titers in histoplasmosis . J. Bacteriol. 89 : 589 - 596 .","journal-title":"J. Bacteriol."}],"container-title":["Journal of Bacteriology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.94.4.798-803.1967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jb.94.4.798-803.1967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T17:26:21Z","timestamp":1627579581000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jb.94.4.798-803.1967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1967,10]]}},"alternative-id":["10.1128\/jb.94.4.798-803.1967"],"URL":"https:\/\/doi.org\/10.1128\/jb.94.4.798-803.1967","relation":{},"ISSN":["0021-9193","1098-5530"],"issn-type":[{"value":"0021-9193","type":"print"},{"value":"1098-5530","type":"electronic"}],"subject":[],"published":{"date-parts":[[1967,10]]},"assertion":[{"value":"2021-02-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}