{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:02:55Z","timestamp":1762210975557},"reference-count":34,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1969,5,1]],"date-time":"1969-05-01T00:00:00Z","timestamp":-21168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1969,5]]},"abstract":"<jats:p>\n            All of 41 naturally occurring coagulase-positive methicillin-resistant strains of\n            <jats:italic>Staphylococcus aureus<\/jats:italic>\n            isolated in various laboratories were resistant to several antibiotics and were lipase-negative. Most strains produced hemolysins, and 38 strains produced enterotoxin B. Acriflavine treatment of four strains resulted in elimination of resistance to methicillin and mercury; in one strain, resistance to cadmium was also lost. Production of enterotoxin B and \u03b2-hemolysin was eliminated in all four strains and penicillinase production was eliminated in one strain. In transduction experiments, methicillin resistance and enterotoxin B production were transferred together at a frequency of 0.2 \u00d7 10\n            <jats:sup>\u22128<\/jats:sup>\n            to 1.1 \u00d7 10\n            <jats:sup>\u22128<\/jats:sup>\n            by use of ultraviolet-induced phage lysates from naturally lysogenic methicillin-resistant strains. Cotransductions of resistance to mercury and cadmium, as well as production of penicillinase and \u03b2-hemolysin, were obtained to some extent. The extrachromosomal character of these determinants and their possible genetic association are discussed.\n          <\/jats:p>","DOI":"10.1128\/jb.98.2.351-358.1969","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T02:16:52Z","timestamp":1578190612000},"page":"351-358","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":71,"title":["Extrachromosomal Control of Methicillin Resistance and Toxin Production in\n            <i>Staphylococcus aureus<\/i>"],"prefix":"10.1128","volume":"98","author":[{"given":"Kathrine","family":"Dornbusch","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Uppsala, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans O.","family":"Hallander","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Uppsala, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"L\u00f6fquist","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, University of Uppsala, Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0006-291X(68)90437-3","article-title":"Regulation of the synthesis of penicillinase in diploids of Staphylococcus aureus","volume":"30","author":"Asheshov E.","year":"1968","unstructured":"Asheshov , E. , and K. 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A. , J. G. Baudens , and G. R. Gerbaud . 1964 . Variations sous l'influence de l'acriflavine et transduction de la resistance a la kanamycin et au chloramphenicol chez les staphylococques . Ann. Inst. Pasteur 107 : 678 - 690 .","journal-title":"Ann. Inst. Pasteur"},{"key":"p_9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/path.1700830209","article-title":"Transduction of tetracycline resistance in staphylococci","volume":"83","author":"Collins A. M.","year":"1962","unstructured":"Collins , A. M. , and S. McDonald , 1962 . Transduction of tetracycline resistance in staphylococci . J. Pathol. Bacteriol. 83 : 399 .","journal-title":"J. Pathol. Bacteriol."},{"key":"p_10","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1139\/m63-069","article-title":"Transduction of chloramphenicol and novobiocin resistance in staphylococci","volume":"9","author":"Collins A. M.","year":"1963","unstructured":"Collins , A. M. , and T. E. Roy . 1963 . 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