{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T07:16:22Z","timestamp":1648970182658},"reference-count":24,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[1969,5,1]],"date-time":"1969-05-01T00:00:00Z","timestamp":-21168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Bacteriol"],"published-print":{"date-parts":[[1969,5]]},"abstract":"<jats:p>\n            The immunization of human beings with paratyphoid B vaccines, in doses producing a marked protective effect in field trials, resulted in H-agglutinin titers that were significantly higher than those produced by ineffective doses. In immunization of rabbits and white mice, the same difference in doses had a significant effect on the ability of vaccines to stimulate the formation of H and O antibodies. A parallel was noted between the effectiveness of vaccine for human beings and the activity of sera of the corresponding group of people in the passive mouse-protection test, with a correlation between such activity of sera and the 19\n            <jats:italic>S<\/jats:italic>\n            O-hemagglutinin titers. The data obtained suggested as promising the determination of agglutinin dynamics in the sera of inoculated human beings and animals to evaluate the antigenic activity of paratyphoid B vaccines in the laboratory. The passive mouse-protection test with human sera holds promise for laboratory evaluation of the effectiveness of paratyphoid B vaccines. At the same time, none of the variation of the active mouse-protection test employed permitted a significant difference to be detected between the vaccines effective and ineffective for man. Comparison of data on the frequency and degree of febrile vaccine reactions in man with results of laboratory evaluation of vaccine toxicity showed that, provided a reference vaccine with known pyrogenic capacity for man was employed, the study of stress effect of vaccines on guinea-pigs (determination of 17-oxycorticosteroid content) may permit prediction of the reactive power of the vaccine. No correlation was found between the pyrogenic capacity of vaccines for man and their toxicity for mice.\n          <\/jats:p>","DOI":"10.1128\/jb.98.2.502-510.1969","type":"journal-article","created":{"date-parts":[[2020,1,5]],"date-time":"2020-01-05T02:17:06Z","timestamp":1578190626000},"page":"502-510","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Laboratory Characteristics of Paratyphoid B Vaccines Tested in Controlled Field Trials"],"prefix":"10.1128","volume":"98","author":[{"given":"L. B.","family":"Hejfec","sequence":"first","affiliation":[{"name":"Laboratory for Study of the Efficacy of Bacterial Preparations, Moscow Mechnikov Institute for Research on Vaccines and Sera, Moscow, Union of Soviet Socialist Republics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. A.","family":"Levina","sequence":"additional","affiliation":[{"name":"Laboratory for Study of the Efficacy of Bacterial Preparations, Moscow Mechnikov Institute for Research on Vaccines and Sera, Moscow, Union of Soviet Socialist Republics"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"p_1","first-page":"51","article-title":"A study of the antigenic structure of typhoid monovaccines by diffuse precipitation in gel","volume":"3","author":"Bencianova T. G.","year":"1967","unstructured":"Bencianova , T. G. 1967 . A study of the antigenic structure of typhoid monovaccines by diffuse precipitation in gel . Zh. Mikrobiol. 3 : 51 - 56 .","journal-title":"Zh. Mikrobiol."},{"key":"p_2","first-page":"43","article-title":"A study of the antigenic structure of a typhoid-paratyphoid B divaccines, tested in epidemiological trial no. 5, 1965","volume":"12","author":"Bencianova T. G.","year":"1967","unstructured":"Bencianova , T. G. 1967 . A study of the antigenic structure of a typhoid-paratyphoid B divaccines, tested in epidemiological trial no. 5, 1965 . Zh. Mikrobiol. 12 : 43 - 47 .","journal-title":"Zh. Mikrobiol."},{"key":"p_3","first-page":"29","article-title":"The present status of field and laboratory studies of typhoid and paratyphoid vaccines with special reference to studies sponsored by W.H.O","volume":"32","author":"Cvjetanovic B.","year":"1965","unstructured":"Cvjetanovic , B. , and K. Uemura . 1965 . The present status of field and laboratory studies of typhoid and paratyphoid vaccines with special reference to studies sponsored by W.H.O . Bull. World Health Organ. 32 : 29 - 36 .","journal-title":"Bull. World Health Organ."},{"key":"p_4","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.125.3248.600","article-title":"Dissociation of human serum macroglobulins","volume":"125","author":"Deutsch H. F.","year":"1957","unstructured":"Deutsch , H. F. , and J. J. Morton . 1957 . Dissociation of human serum macroglobulins . Science 125 : 600 - 601 .","journal-title":"Science"},{"key":"p_5","first-page":"1017","article-title":"Laboratory tests of typhoid vaccines used in a controlled field study","volume":"20","author":"Edsall G.","year":"1959","unstructured":"Edsall , G. , M. J. Carlson , S. B. Formal , and A. S. Benenson . 1959 . Laboratory tests of typhoid vaccines used in a controlled field study . Bull. World Health Organ. 20 : 1017 - 1032 .","journal-title":"Bull. World Health Organ."},{"key":"p_6","unstructured":"Finney D. 1962. Probit analysis. Cambridge Univ. Press New York."},{"key":"p_7","unstructured":"Hald H. 1956. Mathematical statistic with technical appendix. Moscow."},{"key":"p_8","unstructured":"Heifec L. B. 1965. Comparative study of typhoid vaccines in active mouse protection test p. 107-146. In T. A. Nicolaeva (ed.) 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Mikrobiol. 8 : 84 - 92 .","journal-title":"Zh. Mikrobiol."},{"key":"p_14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2105\/AJPH.35.2.153","article-title":"A proposed typhoid immunogenic unit for evaluation of antityphoid immunising substances","volume":"53","author":"Luippold G. F.","year":"1945","unstructured":"Luippold , G. F. 1945 . A proposed typhoid immunogenic unit for evaluation of antityphoid immunising substances . Am. J. Public Health 53 : 153 - 158 .","journal-title":"Am. J. Public Health"},{"key":"p_15","unstructured":"Melikova E. N. S. V. Lesnjak L. D. Peremitina J. J. Lifanova T. S. Sedova W. S. Sezgeeva and T. G. Bencianova. 1965. Comparative study of immunogenic properties of the typhoid vaccines tested in the field trial no. 5 p. 40-50. In Typhoid vaccines Medicina Moscow."},{"key":"p_16","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1128\/JB.91.5.1713-1723.1966","article-title":"Laboratory assays of different types of field trial typhoid vaocines and relationship to efficacy in man","volume":"91","author":"Pittman M.","year":"1966","unstructured":"Pittman , M. , and H. J. Bohner . 1966 . Laboratory assays of different types of field trial typhoid vaocines and relationship to efficacy in man . J. Bacteriol. 91 : 1713 - 1723 .","journal-title":"J. Bacteriol."},{"key":"p_17","first-page":"469","article-title":"Determination of S. typhi 0- and Vi-antibodies by haemagglutination","volume":"39","author":"Spaun J.","year":"1956","unstructured":"Spaun , J. 1956 . Determination of S. typhi 0- and Vi-antibodies by haemagglutination . Acta Pathol. Microbiol. Scand. 39 : 469 - 480 .","journal-title":"Acta Pathol. Microbiol. Scand."},{"key":"p_18","first-page":"793","article-title":"Studies on the influence of route of immunization in the active mouse protection test using intraperitoneal challenge for potency assay of typhoid vaccines","volume":"31","author":"Spaun J.","year":"1964","unstructured":"Spaun , J. 1964 . Studies on the influence of route of immunization in the active mouse protection test using intraperitoneal challenge for potency assay of typhoid vaccines . Bull. World Health Organ. 31 : 793 - 798 .","journal-title":"Bull. World Health Organ."},{"key":"p_19","first-page":"782","article-title":"International reference preparation of typhoid vaccines. A report on international collaborative laboratory studies","volume":"31","author":"Spaun J.","year":"1964","unstructured":"Spaun , J. , and K. Uemura . 1964 . International reference preparation of typhoid vaccines. A report on international collaborative laboratory studies . Bull. World Health Organ. 31 : 782 - 812 .","journal-title":"Bull. World Health Organ."},{"key":"p_20","first-page":"37","article-title":"A report on the laboratory assays carried out at the Lister Institute of Preventive Medicine on the typhoid vaccines used in the field study","volume":"23","author":"Standfast A. F.","year":"1960","unstructured":"Standfast , A. F. 1960 . A report on the laboratory assays carried out at the Lister Institute of Preventive Medicine on the typhoid vaccines used in the field study in Jugoslavia. Bull. World Health Organ. 23 : 37 - 45 .","journal-title":"Jugoslavia. Bull. World Health Organ."},{"key":"p_21","first-page":"57","article-title":"VI antigen content in typhoid vaccines used for the controlled field trials in 1961, in the USSR","volume":"1","author":"Taylor A.","year":"1968","unstructured":"Taylor , A. and T. G. Bencianova . 1968 . VI antigen content in typhoid vaccines used for the controlled field trials in 1961, in the USSR . Przeglad Epidemiologiczny 1 : 57 - 69 .","journal-title":"Przeglad Epidemiologiczny"},{"key":"p_22","unstructured":"Van der Waerden B. L. 1960. Mathematical statistik. Inostrannja Literature Moscow."},{"key":"p_23","first-page":"35","article-title":"Modification of Silber and Porter's method for determination of 17-oxycorticosteroid content in blood","volume":"2","author":"Yudaev N. A.","year":"1958","unstructured":"Yudaev , N. A. , and J. A. Pankov . 1958 . Modification of Silber and Porter's method for determination of 17-oxycorticosteroid content in blood . Prob. Endokrinol. 2 : 35 - 42 .","journal-title":"Prob. Endokrinol."},{"key":"p_24","unstructured":"Zamuchovskaja A. N. Z. V. Razumova V. M. Lavrovskaja and N. I. Kovaleva. 1965. Preparation of typhoid vaccines for the field trial no. 5 p. 33-39. In L. Levina (ed.) 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