{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:04:48Z","timestamp":1793232288593,"version":"4.5.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Campylobacter<\/jats:italic>infection is one of the major causes of ovine abortions worldwide. Historically,<jats:italic>Campylobacter fetus<\/jats:italic>subsp.<jats:italic>fetus<\/jats:italic>was the major cause of<jats:italic>Campylobacter<\/jats:italic>-associated abortion in sheep; however,<jats:italic>Campylobacter jejuni<\/jats:italic>is increasingly associated with sheep abortions. We examined the species distribution, genotypes, and antimicrobial susceptibilities of abortion-associated<jats:italic>Campylobacter<\/jats:italic>isolates obtained from multiple lambing seasons on different farms in Iowa, Idaho, South Dakota, and California. We found that<jats:italic>C. jejuni<\/jats:italic>has replaced<jats:italic>C. fetus<\/jats:italic>as the predominant<jats:italic>Campylobacter<\/jats:italic>species causing sheep abortion in the United States. Most strikingly, the vast majority (66 of 71) of the<jats:italic>C. jejuni<\/jats:italic>isolates associated with sheep abortion belong to a single genetic clone, as determined by pulsed-field gel electrophoresis, multilocus sequence typing, and<jats:italic>cmp<\/jats:italic>gene (encoding the major outer membrane protein) sequence typing. The in vitro antimicrobial susceptibilities of these isolates to the antibiotics that are routinely used in food animal production were determined using the agar dilution test. All of the 74 isolates were susceptible to tilmicosin, florfenicol, tulathromycin, and enrofloxacin, and 97% were sensitive to tylosin. However, all were resistant to tetracyclines, the only antibiotics currently approved in the United States for the treatment of<jats:italic>Campylobacter<\/jats:italic>abortion in sheep. This finding suggests that feeding tetracycline for the prevention of<jats:italic>Campylobacter<\/jats:italic>abortions is ineffective and that other antibiotics should be used for the treatment of sheep abortions in the United States. Together, these results indicate that a single tetracycline-resistant<jats:italic>C. jejuni<\/jats:italic>clone has emerged as the major cause of<jats:italic>Campylobacter<\/jats:italic>-associated sheep abortion in the United States.<\/jats:p>","DOI":"10.1128\/jcm.00031-08","type":"journal-article","created":{"date-parts":[[2008,3,6]],"date-time":"2008-03-06T02:09:46Z","timestamp":1204769386000},"page":"1663-1671","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":111,"title":["Emergence of a Tetracycline-Resistant<i>Campylobacter jejuni<\/i>Clone Associated with Outbreaks of Ovine Abortion in the United States"],"prefix":"10.1128","volume":"46","author":[{"given":"Orhan","family":"Sahin","sequence":"first","affiliation":[{"name":"Departments of Veterinary Microbiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Plummer","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Microbiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna M.","family":"Jordan","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic and Production Animal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapllan","family":"Sulaj","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Microbiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Microbiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suelee","family":"Robbe-Austerman","sequence":"additional","affiliation":[{"name":"National Veterinary Services Laboratories, VS\/APHIS\/USDA, Ames, Iowa 50010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Microbiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Yaeger","sequence":"additional","affiliation":[{"name":"Veterinary Pathology, Iowa State University, Ames, Iowa 50011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine J.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostic and Production Animal Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Microbiology and Preventive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2006.02.014"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/319760"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01513-06"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1139\/w06-099"},{"key":"e_1_3_2_6_2","unstructured":"Supplement M100-S16. 2006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1605(95)00044-K"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2460\/ajvr.1996.57.02.163","volume":"57","year":"1996","unstructured":"Delong, W. 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