{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:41:16Z","timestamp":1784241676456,"version":"3.55.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The Danish Council for Strategic Research","award":["2101-07-0023"],"award-info":[{"award-number":["2101-07-0023"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Dientamoeba fragilis<\/jats:named-content>\n            is an intestinal protozoan of debated clinical significance. Here, we present cross-sectional and longitudinal observations on\n            <jats:named-content content-type=\"genus-species\">D. fragilis<\/jats:named-content>\n            in children aged 0 to 6 years from a 1-year multi-day-care-center cohort study set in Copenhagen, Denmark. The inclusion period for the cohort was 2009 through 2012. Stool samples collected from the children were accompanied by questionnaires completed by the parents or guardians of the children. Using real-time PCR,\n            <jats:named-content content-type=\"genus-species\">D. fragilis<\/jats:named-content>\n            was detected in the first stool sample from 97 of 142 (68.3%) children. We evaluated the associations between seven plausible risk factors (age, sex, having siblings, having domestic animals at home, having had infant colic, recent history of intake of antibiotics, and recent history of travel abroad) as well as six reported symptoms (lack of appetite, nausea, vomiting, abdominal pain, weight loss, and diarrhea) and testing positive for\n            <jats:named-content content-type=\"genus-species\">D. fragilis<\/jats:named-content>\n            . The final multivariable model identified being &gt;3 years old and having a history of recent travel abroad as risk factors for testing positive for\n            <jats:named-content content-type=\"genus-species\">D. fragilis<\/jats:named-content>\n            . Moreover, univariable analyses indicated that having siblings was a risk factor. There was no statistical association between a recent history of gastrointestinal symptoms and testing positive for\n            <jats:named-content content-type=\"genus-species\">D. fragilis<\/jats:named-content>\n            . Among the 108 children who were represented by \u22652 samples and thus included in the longitudinal analysis, 32 tested negative on the first sample and positive later, and the last sample from each of the 108 children was positive. The results are in support of\n            <jats:named-content content-type=\"genus-species\">D. fragilis<\/jats:named-content>\n            being a common enteric commensal in this population.\n          <\/jats:p>","DOI":"10.1128\/jcm.00037-17","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:34:40Z","timestamp":1490229280000},"page":"1707-1713","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":58,"title":["Dientamoeba fragilis, a Commensal in Children in Danish Day Care Centers"],"prefix":"10.1128","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3035-5094","authenticated-orcid":false,"given":"Pikka","family":"Jokelainen","sequence":"first","affiliation":[{"name":"Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark"},{"name":"University of Helsinki, Helsinki, Finland"},{"name":"Estonian University of Life Sciences, Tartu, Estonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betina","family":"Hebbelstrup Jensen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente Utoft","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Munk","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hvidovre University Hospital, Hvidovre, Denmark"},{"name":"Department of Clinical Microbiology, Hvidovre University Hospital, Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"R\u00f6ser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Herlev Hospital, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-3453","authenticated-orcid":false,"given":"Karen A.","family":"Krogfelt","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik V.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1417-7048","authenticated-orcid":false,"given":"Christen R.","family":"Stensvold","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.2.1.14755"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-305942"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089496"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2442-6"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2714-9"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmw111"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004496"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.065"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1880-2"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu188"},{"key":"e_1_3_2_12_2","unstructured":"Hebbelstrup Jensen\nB\n. 2016. Epidemiology and pathological significance of enteroaggregative Escherichia coli in Danish children. PhD thesis. University of Copenhagen Copenhagen Denmark."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/apa.13209"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00075"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcp.2007.05.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.01.005"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.05.005"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2334-9"},{"key":"e_1_3_2_19_2","unstructured":"Dean\nAG\nSullivan\nKM\nSoe\nMM\n. 2016. OpenEpi: open source epidemiologic statistics for public health version 3.01. www.openepi.com. Accessed 7 October 2016."}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00037-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00037-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T09:01:13Z","timestamp":1646470873000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00037-17"}},"subtitle":[],"editor":[{"given":"Peter","family":"Gilligan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1128\/JCM.00037-17"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00037-17","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"2017-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}