{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:26:40Z","timestamp":1788906400495,"version":"build-2803163510"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"The National Science Foundation of China","award":["81071433"],"award-info":[{"award-number":["81071433"]}]},{"name":"China National Science and Technology Major Project Foundation","award":["2012ZX10004215-003-005"],"award-info":[{"award-number":["2012ZX10004215-003-005"]}]},{"name":"China National Science and Technology Major Project Foundation","award":["2016ZX10004215-005-005"],"award-info":[{"award-number":["2016ZX10004215-005-005"]}]},{"name":"Shenzhen Public Service Platform of Pathogenic Microorganisms Repository","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Faculty Baseline Research Funds","award":["KAUST-BRF"],"award-info":[{"award-number":["KAUST-BRF"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Human infections with\n            <jats:named-content content-type=\"genus-species\">Salmonella enterica<\/jats:named-content>\n            subspecies\n            <jats:named-content content-type=\"genus-species\">enterica<\/jats:named-content>\n            serovar Senftenberg are often associated with exposure to poultry flocks, farm environments, or contaminated food. The recent emergence of multidrug-resistant isolates has raised public health concerns. In this study, comparative genomics and phenotypic analysis were used to characterize 14\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            Senftenberg clinical isolates recovered from multiple outbreaks in Shenzhen and Shanghai, China, between 2002 and 2011. Single-nucleotide polymorphism analyses identified two phylogenetically distinct clades of\n            <jats:italic>S<\/jats:italic>\n            . Senftenberg, designated SC1 and SC2, harboring variations in\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            pathogenicity island 1 (SPI-1) and SPI-2 and exhibiting distinct biochemical and phenotypic signatures. Although the two variants shared the same serotype, the SC2 isolates of sequence type 14 (ST14) harbored intact SPI-1 and -2 and hence were characterized by possessing efficient invasion capabilities. In contrast, the SC1 isolates had structural deletion patterns in both SPI-1 and -2 that correlated with an impaired capacity to invade cultured human cells and also the year of their isolation. These atypical SC1 isolates also lacked the capacity to produce hydrogen sulfide. These findings highlight the emergence of atypical\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            Senftenberg variants in China and provide genetic validation that variants lacking SPI-1 and regions of SPI-2, which leads to impaired invasion capacity, can still cause clinical disease. These data have identified an emerging public health concern and highlight the need to strengthen surveillance to detect the prevalence and transmission of nontyphoidal\n            <jats:named-content content-type=\"genus-species\">Salmonella<\/jats:named-content>\n            species.\n          <\/jats:p>","DOI":"10.1128\/jcm.00052-16","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T03:35:27Z","timestamp":1464233727000},"page":"2014-2022","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Genomic and Phenotypic Analyses Reveal the Emergence of an Atypical Salmonella enterica Serovar Senftenberg Variant in China"],"prefix":"10.1128","volume":"54","author":[{"given":"Moataz","family":"Abd El Ghany","sequence":"first","affiliation":[{"name":"King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Shi","sequence":"additional","affiliation":[{"name":"Shenzhen Centre for Disease Control and Prevention, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Centre for Disease Control and Prevention, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hifzur R.","family":"Ansari","sequence":"additional","affiliation":[{"name":"King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant A.","family":"Hill-Cawthorne","sequence":"additional","affiliation":[{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity and School of Public Health, University of Sydney, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. S.","family":"Ho","sequence":"additional","affiliation":[{"name":"King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raeece","family":"Naeem","sequence":"additional","affiliation":[{"name":"King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Pickard","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Sanger Institute (WTSI), the Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Klena","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebing","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnab","family":"Pain","sequence":"additional","affiliation":[{"name":"King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Hu","sequence":"additional","affiliation":[{"name":"Shenzhen Centre for Disease Control and Prevention, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/650733"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2106.140999"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-11-058"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1701.P11101"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.5.2249-2255.2002"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.9.4270-4278.2003"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002776"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81985-6"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-365"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01389-09"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015750"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.044941-0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.45"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01255-07"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035782"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/03079450802216561"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0195-6701(92)90017-G"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.4.734"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268897008546"},{"key":"e_1_3_3_21_2","first-page":"E070614.3","article-title":"International outbreak of Salmonella Senftenberg in 2007","volume":"12","author":"Pezzoli L","year":"2007","unstructured":"Pezzoli L, Elson R, Little C, Fisher I, Yip H, Peters T, Hampton M, De Pinna E, Coia JE, Mather HA, Brown DJ, Nielsen EM, Ethelberg S, Heck M, de Jager C, Threlfall J. 2007. International outbreak of Salmonella Senftenberg in 2007. Euro Surveill 12:E070614.3.","journal-title":"Euro Surveill"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1605.091555"},{"key":"e_1_3_3_23_2","first-page":"933","article-title":"Study on the epidemiological characteristics and molecular typing of Salmonella enterica subsp. enterica serovar Senftenberg in Shanghai","volume":"30","author":"Xu XB","year":"2009","unstructured":"Xu XB, Yuan ZA, Jin HM, Xiao WJ, Gu BK, Chen M, Ran L, Diao BW, Cui ZG, Hu QH, Kan B. 2009. Study on the epidemiological characteristics and molecular typing of Salmonella enterica subsp. enterica serovar Senftenberg in Shanghai. Zhonghua Liu Xing Bing Xue Za Zhi 30:933\u2013937. (In Chinese.)","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-11-153"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02227-12"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1906.121515"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00377-14"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2002.00170.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-13-88"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl446"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msj030"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.074492.107"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp347"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-4-r41"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu153"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.2289704"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn529"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06094-11"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1224503"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00255-12"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04666.x"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01655-06"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M503076200"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02225-12"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature09415"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107857108"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.4.981-986.1995"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1139\/W10-005"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1021\/es012337m"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-092611-150159"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2651"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003827"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00052-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00052-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T08:53:33Z","timestamp":1646470413000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00052-16"}},"subtitle":[],"editor":[{"given":"D. J.","family":"Diekema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1128\/JCM.00052-16"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00052-16","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"2016-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}