{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:23:15Z","timestamp":1777648995544,"version":"3.51.4"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            TDT 067 is a novel carrier-based dosage form (liquid spray) of 15 mg\/ml of terbinafine in Transfersome that has been developed to deliver terbinafine to the nail bed to treat onychomycosis. In this study, we report the\n            <jats:named-content content-type=\"genus-species\">in vitro<\/jats:named-content>\n            activities of TDT 067 against dermatophytes, compared with those of the Transfersome vehicle, naked terbinafine, and commercially available terbinafine (1%) spray. The MICs of TDT 067 and comparators against 25 clinical strains each of\n            <jats:named-content content-type=\"genus-species\">Trichophyton rubrum<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">T. mentagrophytes<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">Epidermophyton floccosum<\/jats:named-content>\n            were determined according to the CLSI M38\u2013A2 susceptibility method (2008). Minimum fungicidal concentrations (MFCs) were determined by subculturing visibly clear wells from the MIC microtiter plates. TDT 067 demonstrated potent activity against the dermatophyte strains tested, with an MIC range of 0.00003 to 0.015 \u03bcg\/ml. Overall, TDT 067 MIC\n            <jats:sub>50<\/jats:sub>\n            values (defined as the lowest concentrations to inhibit 50% of the strains tested) were 8-fold and 60-fold lower than those of naked terbinafine and terbinafine spray, respectively. The Transfersome vehicle showed minimal inhibitory activity. TDT 067 demonstrated lower MFC values for\n            <jats:named-content content-type=\"genus-species\">T. rubrum<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">E. floccosum<\/jats:named-content>\n            than naked terbinafine and terbinafine spray. TDT 067 has more potent antifungal activity against dermatophytes that cause nail infection than conventional terbinafine preparations. The Transfersome vehicle appears to potentiate the antifungal activity of terbinafine. Clinical investigation of TDT 067 for the topical treatment of onychomycosis is warranted.\n          <\/jats:p>","DOI":"10.1128\/jcm.00083-11","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T00:54:24Z","timestamp":1300323264000},"page":"1716-1720","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":53,"title":["Activity of TDT 067 (Terbinafine in Transfersome) against Agents of Onychomycosis, as Determined by Minimum Inhibitory and Fungicidal Concentrations"],"prefix":"10.1128","volume":"49","author":[{"given":"Mahmoud","family":"Ghannoum","sequence":"first","affiliation":[{"name":"Center for Medical Mycology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Isham","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Herbert","sequence":"additional","affiliation":[{"name":"Center for Medical Mycology, Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Henry","sequence":"additional","affiliation":[{"name":"Celtic Pharma Development Services Europe Ltd., London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Yurdakul","sequence":"additional","affiliation":[{"name":"Celtic Pharma Development Services Europe Ltd., London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81262-5"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1365-2133.2007.07974.x","article-title":"A multicentre, randomized, controlled study of the efficacy, safety and cost-effectiveness of a combination therapy with amorolfine nail lacquer and oral terbinafine compared with oral terbinafine alone for the treatment of onychomycosis with matrix involvement","volume":"157","author":"Baran R.","year":"2007","unstructured":"BaranR. . 2007. 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