{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:05:52Z","timestamp":1791389152473,"version":"4.3.3"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2703603"],"award-info":[{"award-number":["2022YFC2703603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701800"],"award-info":[{"award-number":["2021YFC2701800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2701805"],"award-info":[{"award-number":["2021YFC2701805"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22Y11902700"],"award-info":[{"award-number":["22Y11902700"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004241","name":"China Primary Health Care Foundation","doi-asserted-by":"publisher","award":["MTP2022A014"],"award-info":[{"award-number":["MTP2022A014"]}],"id":[{"id":"10.13039\/501100004241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC22020217"],"award-info":[{"award-number":["SHDC22020217"]}],"id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2023,6,20]]},"abstract":"<jats:p>Metagenomic next-generation sequencing (mNGS) has shown promise in the diagnosis of infectious diseases in adults, while its efficacy in pediatric infections remains uncertain. We performed a retrospective analysis of 1,493 mNGS samples from pediatric patients with blood, central nervous system, and lower respiratory tract infections.<\/jats:p>","DOI":"10.1128\/jcm.00115-23","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T10:02:37Z","timestamp":1685613757000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":40,"title":["Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing for Pediatric Infectious Diseases"],"prefix":"10.1128","volume":"61","author":[{"given":"Yunqian","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neonatology, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Gan","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"},{"name":"Key Laboratory of Birth Defects, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Dong","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"},{"name":"Key Laboratory of Birth Defects, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangfeng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinhua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9269-4414","authenticated-orcid":true,"given":"Bingbing","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"},{"name":"Key Laboratory of Birth Defects, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"},{"name":"Center for Molecular Medicine, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"},{"name":"Key Laboratory of Birth Defects, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"},{"name":"Key Laboratory of Neonatal Diseases, Ministry of Health, Children\u2019s Hospital of Fudan University, National Children\u2019s Medical Center, Shanghai, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32154-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30063-8"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31002-4"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2323OC"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1803396"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j686"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013864.pub2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1105-z"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0113-7"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01572-4"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012751"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa035"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00419-20"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003395"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00794-20"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvac067"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.PCC.0000149131.72248.E6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001936"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0349-6"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02360-6"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.671109"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy693"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4132-y"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1516"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01410-21"}],"updated-by":[{"DOI":"10.1128\/jcm.01150-23","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000}}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.00115-23","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.00115-23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T09:01:47Z","timestamp":1687251707000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jcm.00115-23"}},"subtitle":[],"editor":[{"given":"Erin","family":"McElvania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,6,20]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,20]]}},"alternative-id":["10.1128\/jcm.00115-23"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00115-23","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,20]]},"assertion":[{"value":"2023-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00115-23"}}