{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:54:45Z","timestamp":1761580485569},"reference-count":19,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We reevaluated\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            disk diffusion breakpoints for the tetracyclines published in the Clinical and Laboratory Standards Institute (CLSI) document M100-S16, which were (susceptible\/resistant) \u226519 mm\/\u226414 mm for tetracycline, \u226516 mm\/\u226412 mm for doxycycline, and \u226519 mm\/\u226414 mm for minocycline. A collection of 504 recent clinical isolates of\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            were tested against these tetracycline compounds by disk diffusion and broth microdilution methods according to CLSI guidelines. Regression line and scattergram plot analyses determined intermethod accuracy for current disk diffusion breakpoints and showed excellent\n            <jats:italic>r<\/jats:italic>\n            values of 0.91 to 0.95. However, error rates (minor\/major [false-resistant]\/very major [false-susceptible]) were 14.9\/0.8\/0.0% for tetracycline, 11.5\/0.4\/0.0% for doxycycline, and 30.6\/0.7\/0.0% for minocycline and only 4.4\/0.0\/0.0% for tetracycline, 5.6\/0.0\/0.2% for doxycycline, and 8.3\/0.0\/0.3% for minocycline when proposed breakpoints were modified to (susceptible\/resistant) \u226515 mm\/\u226411 mm for tetracycline, \u226514 mm\/\u226410 mm for doxycycline, and \u226516 mm\/\u226412 mm for minocycline. Listed modifications were recently approved by the CLSI (M100-S17).\n          <\/jats:p>","DOI":"10.1128\/jcm.00143-07","type":"journal-article","created":{"date-parts":[[2007,3,15]],"date-time":"2007-03-15T00:31:30Z","timestamp":1173918690000},"page":"1640-1643","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":21,"title":["Reevaluation of Clinical and Laboratory Standards Institute Disk Diffusion Breakpoints for Tetracyclines for Testing\n            <i>Enterobacteriaceae<\/i>"],"prefix":"10.1128","volume":"45","author":[{"given":"Helio S.","family":"Sader","sequence":"first","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary J.","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Barth","family":"Reller","sequence":"additional","affiliation":[{"name":"Duke University, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Schreckenberger","sequence":"additional","affiliation":[{"name":"Loyola University Chicago, Chicago, Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana M.","family":"Swenson","sequence":"additional","affiliation":[{"name":"CDC, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald N.","family":"Jones","sequence":"additional","affiliation":[{"name":"JMI Laboratories, North Liberty, Iowa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl224"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-4-482"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/70.5.821"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinmicnews.2004.10.001"},{"key":"e_1_3_1_6_2","first-page":"642","volume":"1","year":"2005","unstructured":"Bryskier, A. 2005. Tetracyclines, p. 642-651. In A. Bryskier (ed.), Antimicrobial agents: antibacterials and antifungals, vol. 1. ASM Press, Washington, DC.","journal-title":"Antimicrobial agents: antibacterials and antifungals"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.65.2.232-260.2001"},{"key":"e_1_3_1_8_2","unstructured":"Clinical and Laboratory Standards Institute 2006"},{"key":"e_1_3_1_9_2","unstructured":"Clinical and Laboratory Standards Institute 2006"},{"key":"e_1_3_1_10_2","unstructured":"Clinical and Laboratory Standards Institute 2006"},{"key":"e_1_3_1_11_2","unstructured":"Clinical and Laboratory Standards Institute 2007"},{"key":"e_1_3_1_12_2","first-page":"115","volume":"4","year":"1982","unstructured":"Cunha, B. A., C. M. Sibley, and A. M. Ristuccia. 1982. Doxycycline. Ther. Drug Monit.4:115-135.","journal-title":"Ther. Drug Monit."},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1948.tb27262.x"},{"key":"e_1_3_1_14_2","unstructured":"National Committee for Clinical Laboratory Standards 1976"},{"key":"e_1_3_1_15_2","unstructured":"National Committee for Clinical Laboratory Standards 1979"},{"key":"e_1_3_1_16_2","unstructured":"National Committee for Clinical Laboratory Standards 1981"},{"key":"e_1_3_1_17_2","unstructured":"National Committee for Clinical Laboratory Standards 1982"},{"key":"e_1_3_1_18_2","unstructured":"National Committee for Clinical Laboratory Standards 2001"},{"key":"e_1_3_1_19_2","first-page":"141","volume":"54","year":"1978","unstructured":"Neu, H. C. 1978. A symposium on the tetracyclines: a major appraisal. Introduction. Bull. N. Y. Acad. Med. 54:141-155.","journal-title":"A symposium on the tetracyclines: a major appraisal"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4793-4799.2004"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00143-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00143-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T05:46:52Z","timestamp":1646459212000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00143-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["10.1128\/JCM.00143-07"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00143-07","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]},"assertion":[{"value":"2007-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-03-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}