{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T17:09:46Z","timestamp":1769101786832,"version":"3.49.0"},"reference-count":56,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Cervicitis is a common clinical finding often attributed to sexually transmitted infections (STIs), but no etiologic agent is identified in the majority of cases. In this study, we comparatively assessed inflammation among the common infectious etiologies of cervicitis and assessed the potential value of liquid cytology specimens for predicting STIs. Among 473 Louisiana women at low risk for acquiring STIs, the prevalences of\n            <jats:named-content content-type=\"genus-species\">Mycoplasma genitalium<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Chlamydia trachomatis<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Neisseria gonorrhoeae<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">Trichomonas vaginalis<\/jats:named-content>\n            in liquid-based cytology specimens were 1.5, 2.1, 0.6, and 4.4%, respectively.\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            and human papillomavirus 18 (HPV18) infections were significantly more common among subjects infected with\n            <jats:named-content content-type=\"genus-species\">M. genitalium<\/jats:named-content>\n            . Using direct microscopy, we observed significant increases in leukocyte infiltrates among subjects with monoinfections with\n            <jats:named-content content-type=\"genus-species\">M. genitalium<\/jats:named-content>\n            or\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            compared to women with no detectable STIs. Inflammation was highest among subjects with\n            <jats:named-content content-type=\"genus-species\">M. genitalium<\/jats:named-content>\n            . Using a threshold of \u22652 leukocytes per epithelial cell per high-powered field, the positive predictive values for\n            <jats:named-content content-type=\"genus-species\">M. genitalium<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">C. trachomatis<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">N. gonorrhoeae<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">T. vaginalis<\/jats:named-content>\n            were 100, 70, 67, and 20%, respectively. Several novel\n            <jats:named-content content-type=\"genus-species\">M. genitalium<\/jats:named-content>\n            genotypes were identified, all of which were predicted to be susceptible to macrolide antibiotics, suggesting that different strains may circulate among low-risk women and that macrolide resistance is substantially lower than in high-risk populations. This study highlights the capacity of\n            <jats:named-content content-type=\"genus-species\">M. genitalium<\/jats:named-content>\n            to elicit cervical inflammation and, considering the strong epidemiologic associations between\n            <jats:named-content content-type=\"genus-species\">M. genitalium<\/jats:named-content>\n            and human immunodeficiency virus (HIV), provides a potential mechanism for acquisition and shedding of HIV via chronic leukocyte recruitment to the cervical mucosa.\n          <\/jats:p>","DOI":"10.1128\/jcm.00159-14","type":"journal-article","created":{"date-parts":[[2014,4,24]],"date-time":"2014-04-24T03:17:39Z","timestamp":1398309459000},"page":"2398-2405","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Mycoplasma genitalium Infection Is Associated with Microscopic Signs of Cervical Inflammation in Liquid Cytology Specimens"],"prefix":"10.1128","volume":"52","author":[{"given":"Patricia M.","family":"Dehon","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris L.","family":"McGowin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"},{"name":"Department of Internal Medicine, Section of Infectious Diseases, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0b013e3181b01948"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198407053110101"},{"key":"e_1_3_2_4_2","first-page":"1","article-title":"Sexually transmitted diseases treatment guidelines, 2010","volume":"59","author":"Workowski KA","year":"2010","unstructured":"WorkowskiKA BermanS. 2010. 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