{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:10:53Z","timestamp":1790118653232,"version":"4.0.1"},"reference-count":11,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The case of a patient with visceral leishmaniasis showing inadequate response to amphotericin B from a region where leishmaniasis is not endemic is reported, with the\n                    <jats:named-content content-type=\"genus-species\">Leishmania donovani<\/jats:named-content>\n                    isolate showing increased tolerance to amphotericin B\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Four single nucleotide polymorphisms (SNPs) detected in the cysteine proteinase B gene resulted in changes to the deduced amino acid sequence: valine\u2192alanine and arginine\u2192leucine. Overexpression and underexpression of proteins were observed in the 65- to 80-kDa range and at 20 kDa, respectively.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00173-11","type":"journal-article","created":{"date-parts":[[2011,5,26]],"date-time":"2011-05-26T01:21:46Z","timestamp":1306372906000},"page":"3088-3091","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":62,"title":["Unusual Case of Resistance to Amphotericin B in Visceral Leishmaniasis in a Region in India Where Leishmaniasis Is Not Endemic"],"prefix":"10.1128","volume":"49","author":[{"given":"Pankaj","family":"Srivastava","sequence":"first","affiliation":[{"name":"Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay Kumar","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhukar","family":"Rai","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Sundar","sequence":"additional","affiliation":[{"name":"Infectious Disease Research Laboratory, Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.720"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.77.95"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/595710"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn189"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/382049"},{"key":"e_1_3_2_9_2","first-page":"8","article-title":"Characteristics of Leishmania spp. isolated from a mixed focus of cutaneous and visceral leishmaniasis in Himachal Pradesh (India)","volume":"7","author":"Sharma N. L.","year":"2009","unstructured":"SharmaN. L. . 2009. Characteristics of Leishmania spp. isolated from a mixed focus of cutaneous and visceral leishmaniasis in Himachal Pradesh (India). Internet J. Third World Med. 7:8.","journal-title":"Internet J. Third World Med."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/expr.2001.4663"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/318121"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(99)00133-8"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00173-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00173-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T07:53:06Z","timestamp":1646466786000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00173-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":11,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1128\/JCM.00173-11"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00173-11","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]},"assertion":[{"value":"2011-01-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}