{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:16:24Z","timestamp":1791155784500,"version":"4.1.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2009,8,1]],"date-time":"2009-08-01T00:00:00Z","timestamp":1249084800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>The objective of this study was to evaluate the performance of a low-cost method, the thin layer agar (TLA) method, for the diagnosis of smear-negative patients. This prospective study was performed in Homa Bay District Hospital in Kenya. Out of 1,584 smear-negative sputum samples, 212 (13.5%) were positive by culture in Lo\u0308wenstein-Jensen medium (LJ) and 220 (14%) were positive by the TLA method. The sensitivities of LJ and TLA were 71% and 74%, respectively. TLA could become an affordable method for the diagnosis of smear-negative tuberculosis in resource-limited settings, with results available within 2 weeks.<\/jats:p>","DOI":"10.1128\/jcm.00264-09","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T01:35:55Z","timestamp":1244079355000},"page":"2632-2634","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Implementation of the Thin Layer Agar Method for Diagnosis of Smear-Negative Pulmonary Tuberculosis in a Setting with a High Prevalence of Human Immunodeficiency Virus Infection in Homa Bay, Kenya"],"prefix":"10.1128","volume":"47","author":[{"given":"Anandi","family":"Martin","sequence":"first","affiliation":[{"name":"Institute of Tropical Medicine, Antwerp, Belgium"},{"name":"Me\u0301decins Sans Frontie\u0300res, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Munga Waweru","sequence":"additional","affiliation":[{"name":"Homa Bay District Hospital, Nyanza, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Babu Okatch","sequence":"additional","affiliation":[{"name":"Homa Bay District Hospital, Nyanza, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naureen","family":"Amondi Ouma","sequence":"additional","affiliation":[{"name":"Homa Bay District Hospital, Nyanza, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bonte","sequence":"additional","affiliation":[{"name":"Me\u0301decins Sans Frontie\u0300res, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Varaine","sequence":"additional","affiliation":[{"name":"Me\u0301decins Sans Frontie\u0300res, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327oise","family":"Portaels","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(80)90001-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-83822007000300007"},{"key":"e_1_3_2_4_2","first-page":"97","volume":"4","year":"2000","unstructured":"Colebunders, R., and I. 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