{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:49:31Z","timestamp":1790228971343,"version":"4.1.0"},"reference-count":27,"publisher":"American Society for Microbiology","issue":"10","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>hom<\/jats:italic>\n                    family of\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    outer-membrane proteins, especially the\n                    <jats:italic>homB<\/jats:italic>\n                    gene, has been suggested as a novel virulence factor; however, the clinical association and function of this gene are still unclear. We evaluated the presence of the\n                    <jats:italic>homA<\/jats:italic>\n                    ,\n                    <jats:italic>homB<\/jats:italic>\n                    , and\n                    <jats:italic>cagA<\/jats:italic>\n                    genes in 286 strains isolated from patients in the U.S. and Colombian populations (126 with gastritis, 96 with duodenal ulcer, and 64 with gastric cancer) by PCR. The results were compared with the clinical presentation and gastric injury. The prevalence of the\n                    <jats:italic>homB<\/jats:italic>\n                    gene was significantly higher in strains isolated from gastric-cancer patients (71.9%) than in those from duodenal ulcer patients (52.1%) (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.012). In a multivariate analysis, the presence of the\n                    <jats:italic>cagA<\/jats:italic>\n                    gene significantly increased the risk for developing gastric cancer and duodenal ulcer, with the presence of the\n                    <jats:italic>homB<\/jats:italic>\n                    gene acting as a factor that could distinguish gastric cancer from duodenal ulcer (adjusted odds ratio, 3.033; 95% confidence interval, \u223c1.37 to \u223c6.73).\n                    <jats:italic>cagA<\/jats:italic>\n                    status was correlated with\n                    <jats:italic>homB<\/jats:italic>\n                    status (\n                    <jats:italic>r<\/jats:italic>\n                    = 0.323;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01). A histological analysis showed that\n                    <jats:italic>cagA<\/jats:italic>\n                    status was associated with inflammation and atrophy both in the antrum and in the corpus, while\n                    <jats:italic>homB<\/jats:italic>\n                    status was associated with inflammation and atrophy in the corpus.\n                    <jats:italic>homB<\/jats:italic>\n                    gene status might be susceptible to gastric-cancer development such that the\n                    <jats:italic>homB<\/jats:italic>\n                    gene is used as a factor for discriminating the risk of gastric cancer from that of duodenal ulcer.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00293-09","type":"journal-article","created":{"date-parts":[[2009,8,26]],"date-time":"2009-08-26T21:45:10Z","timestamp":1251323110000},"page":"3241-3245","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":50,"title":["<i>homB<\/i>\n                    Status of\n                    <i>Helicobacter pylori<\/i>\n                    as a Novel Marker To Distinguish Gastric Cancer from Duodenal Ulcer"],"prefix":"10.1128","volume":"47","author":[{"given":"Sung Woo","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas"},{"name":"Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsushige","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Y.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas"},{"name":"Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4155-4168.2000"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00557.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/522177"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.1.110304.100125"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.041"},{"key":"e_1_3_2_7_2","first-page":"2111","volume":"55","year":"1995","unstructured":"Blaser, M. J., G. I. Perez-Perez, H. Kleanthous, T. L. Cover, R. M. Peek, P. H. Chyou, G. N. Stemmermann, and A. Nomura. 1995. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res.55:2111-2115.","journal-title":"Cancer Res."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90135-5"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850170973"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12778"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.05.006"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70019-2"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.01.009"},{"key":"e_1_3_2_14_2","first-page":"32","volume":"215","year":"1996","unstructured":"McColl, K. E., and E. el-Omar. 1996. Helicobacter pylori and disturbance of gastric function associated with duodenal ulcer disease and gastric cancer. Scand. J. Gastroenterol. 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