{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:02:17Z","timestamp":1791223337385,"version":"4.1.0"},"reference-count":68,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Despite increasing reports of human infection, data about the optimal care of\n            <jats:named-content content-type=\"genus-species\">Phaeoacremonium<\/jats:named-content>\n            infections are missing. We report a case of an infection due to\n            <jats:named-content content-type=\"genus-species\">Phaeoacremonium parasiticum<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Paraconiothyrium cyclothyrioides<\/jats:named-content>\n            , initially localized to skin and soft tissue, in a kidney transplant patient. Despite surgical drainage and excision of the lesion and combination antifungal therapy with voriconazole and liposomal amphotericin B, a disseminated infection involving the lungs and brain developed and led to death. We performed a systematic literature review to assess the general features and outcome of human infections due to\n            <jats:named-content content-type=\"genus-species\">Phaeoacremonium<\/jats:named-content>\n            species. Thirty-six articles were selected, and 42 patients, including ours, were reviewed. Thirty-one patients (74%) were immunocompromised because of organ or bone marrow transplantation (\n            <jats:italic>n<\/jats:italic>\n            = 17), diabetes or glucose intolerance (\n            <jats:italic>n<\/jats:italic>\n            = 10), rheumatoid arthritis or Still's disease (\n            <jats:italic>n<\/jats:italic>\n            = 4), chronic hematological diseases (\n            <jats:italic>n<\/jats:italic>\n            = 3), or chronic granulomatous disease (\n            <jats:italic>n<\/jats:italic>\n            = 3). Ten patients (24%) reported initial cutaneous trauma. Skin and soft tissue infections represented 57% of infections (\n            <jats:italic>n<\/jats:italic>\n            = 24), and disseminated infections, all occurring in immunocompromised patients, represented 14% of infections (\n            <jats:italic>n<\/jats:italic>\n            = 6). The main antifungal drugs used were azoles (\n            <jats:italic>n<\/jats:italic>\n            = 41) and amphotericin B (\n            <jats:italic>n<\/jats:italic>\n            = 16). Surgical excision or drainage was performed in 64% of cases (\n            <jats:italic>n<\/jats:italic>\n            = 27). The cure rate was 67% (\n            <jats:italic>n<\/jats:italic>\n            = 28). There were 10% cases of treatment failure or partial response (\n            <jats:italic>n<\/jats:italic>\n            = 4), 19% relapses (\n            <jats:italic>n<\/jats:italic>\n            = 8), and 7% losses to follow-up (\n            <jats:italic>n<\/jats:italic>\n            = 3). The death rate was 19% (\n            <jats:italic>n<\/jats:italic>\n            = 8). Management of\n            <jats:named-content content-type=\"genus-species\">Phaeoacremonium<\/jats:named-content>\n            infections is complex because of slow laboratory identification and limited clinical data, and treatment relies on a combination of surgery and systemic antifungal therapy.\n          <\/jats:p>","DOI":"10.1128\/jcm.00295-15","type":"journal-article","created":{"date-parts":[[2015,4,23]],"date-time":"2015-04-23T02:41:05Z","timestamp":1429756865000},"page":"2084-2094","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Dual Invasive Infection with Phaeoacremonium parasiticum and Paraconiothyrium cyclothyrioides in a Renal Transplant Recipient: Case Report and Comprehensive Review of the Literature of Phaeoacremonium Phaeohyphomycosis"],"prefix":"10.1128","volume":"53","author":[{"given":"Marie-Alice","family":"Colombier","sequence":"first","affiliation":[{"name":"Service de Maladies 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