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We examined the prevalence, resistance, and molecular diversity of\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    in the general population in Northeast Germany. Nasal swabs were obtained from 3,891 adults in the large-scale population-based Study of Health in Pomerania (SHIP-TREND). Isolates were characterized using\n                    <jats:italic>spa<\/jats:italic>\n                    genotyping, as well as antibiotic resistance and virulence gene profiling. We observed an\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    prevalence of 27.2%. Nasal\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    carriage was associated with male sex and inversely correlated with age. Methicillin-resistant\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    (MRSA) accounted for 0.95% of the colonizing\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    strains. MRSA carriage was associated with frequent visits to hospitals, nursing homes, or retirement homes within the previous 24 months. All MRSA strains were resistant to multiple antibiotics. Most MRSA isolates belonged to the pandemic European hospital-acquired MRSA sequence type 22 (HA-MRSA-ST22) lineage. We also detected one livestock-associated MRSA ST398 (LA-MRSA-ST398) isolate, as well as six livestock-associated methicillin-susceptible\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    (LA-MSSA) isolates (clonal complex 1 [CC1], CC97, and CC398).\n                    <jats:italic>spa<\/jats:italic>\n                    typing revealed a diverse but also highly clonal\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    population structure. We identified a total of 357\n                    <jats:italic>spa<\/jats:italic>\n                    types, which were grouped into 30 CCs or sequence types. The major seven CCs (CC30, CC45, CC15, CC8, CC7, CC22, and CC25) included 75% of all isolates. Virulence gene patterns were strongly linked to the clonal background. In conclusion, MSSA and MRSA prevalences and the molecular diversity of\n                    <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n                    in Northeast Germany are consistent with those of other European countries. The detection of HA-MRSA and LA-MRSA within the general population indicates possible transmission from hospitals and livestock, respectively, and should be closely monitored.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00312-16","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T22:28:56Z","timestamp":1473287336000},"page":"2774-2785","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["Molecular Epidemiology of Staphylococcus aureus in the General Population in Northeast Germany: Results of the Study of Health in Pomerania (SHIP-TREND-0)"],"prefix":"10.1128","volume":"54","author":[{"given":"Silva","family":"Holtfreter","sequence":"first","affiliation":[{"name":"Department of Immunology, University Medicine Greifswald, Greifswald, 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