{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:52:27Z","timestamp":1791917547568,"version":"4.3.4"},"reference-count":41,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2023,11,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The bioM\u00e9rieux BIOFIRE Joint Infection (JI) Panel is a multiplex\n            <jats:italic>in vitro<\/jats:italic>\n            diagnostic test for the simultaneous and rapid (~1 h) detection of 39 potential pathogens and antimicrobial resistance (AMR) genes directly from synovial fluid (SF) samples. Thirty-one species or groups of microorganisms are included in the kit, as well as several AMR genes. This study, performed to evaluate the BIOFIRE JI Panel for regulatory clearance, provides data from a multicenter evaluation of 1,544 prospectively collected residual SF samples with performance compared to standard-of-care (SOC) culture for organisms or polymerase chain reaction (PCR) and sequencing for AMR genes. The BIOFIRE JI Panel demonstrated a sensitivity of 90.9% or greater for all but six organisms and a positive percent agreement (PPA) of 100% for all AMR genes. The BIOFIRE JI Panel demonstrated a specificity of 98.5% or greater for detection of all organisms and a negative percent agreement (NPA) of 95.7% or greater for all AMR genes. The BIOFIRE JI Panel provides an improvement over SOC culture, with a substantially shorter time to result for both organisms and AMR genes with excellent sensitivity\/PPA and specificity\/NPA, and is anticipated to provide timely and actionable diagnostic information for joint infections in a variety of clinical scenarios.\n          <\/jats:p>","DOI":"10.1128\/jcm.00357-23","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T13:01:12Z","timestamp":1698238872000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":54,"title":["Multicenter evaluation of the BIOFIRE Joint Infection Panel for the detection of bacteria, yeast, and AMR genes in synovial fluid samples"],"prefix":"10.1128","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-3167","authenticated-orcid":true,"given":"Jaime","family":"Esteban","sequence":"first","affiliation":[{"name":"IIS-Fundacion Jimenez Diaz, CIBERINFEC-CIBER de Enfermedades Infecciosas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Llanos","family":"Salar-Vidal","sequence":"additional","affiliation":[{"name":"IIS-Fundacion Jimenez Diaz, CIBERINFEC-CIBER de Enfermedades Infecciosas , Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan H.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine , Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Waggoner","sequence":"additional","affiliation":[{"name":"Indiana University School of Medicine , Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Laurent","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon , Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lelia","family":"Abad","sequence":"additional","affiliation":[{"name":"Hospices Civils de Lyon , Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving","family":"Mazariegos","sequence":"additional","affiliation":[{"name":"Hospital for Special Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan-Miquel","family":"Balada-Llasat","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center , Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Horn","sequence":"additional","affiliation":[{"name":"The Ohio State University Wexner Medical Center , Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-5135","authenticated-orcid":true,"given":"Donna M.","family":"Wolk","sequence":"additional","affiliation":[{"name":"Geisinger Health , Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa","family":"Jefferis","sequence":"additional","affiliation":[{"name":"Geisinger Health , Danville, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"Hermans","sequence":"additional","affiliation":[{"name":"Jeroen Bosch Hospital , Den Bosch, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Verhoofstad","sequence":"additional","affiliation":[{"name":"Jeroen Bosch Hospital , Den Bosch, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-8706","authenticated-orcid":true,"given":"Susan M.","family":"Butler-Wu","sequence":"additional","affiliation":[{"name":"University of Southern California , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minette","family":"Umali-Wilcox","sequence":"additional","affiliation":[{"name":"University of Southern California , Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Murphy","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha , Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Cabrera","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha , Omaha, Nebraska, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Craft","sequence":"additional","affiliation":[{"name":"The Milton S. 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