{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:29:27Z","timestamp":1792268967540,"version":"4.4.0"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>, a large group of environmental Gram-negative bacteria, represents an occasional cause of pneumonia. We analyzed the microbiological and clinical features of 33 consecutive cases of<jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>infections that occurred at the University of Texas MD Anderson Cancer Center, Houston, TX, from 2002 to 2014. The<jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>strains were isolated from bronchoscopy specimens (32 strains) and a blood culture (1 strain) and were identified by sequencing analysis of the full-length 16S rRNA gene. The 33 strains involved 12<jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>species or subspecies: 15 strains of<jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>subsp.<jats:named-content content-type=\"genus-species\">pneumophila<\/jats:named-content>, 3 strains of<jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>subsp.<jats:named-content content-type=\"genus-species\">fraseri<\/jats:named-content>or<jats:named-content content-type=\"genus-species\">L. pneumophila<\/jats:named-content>subsp.<jats:named-content content-type=\"genus-species\">pascullei<\/jats:named-content>, 4 strains of \u201c<jats:named-content content-type=\"genus-species\">L. donaldsonii<\/jats:named-content>,\u201d 3 strains of<jats:named-content content-type=\"genus-species\">L. micdadei<\/jats:named-content>, and one each of<jats:named-content content-type=\"genus-species\">L. bozemanae<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">L. feeleii<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">L. gormanii<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">L. longbeachae<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">L. maceachernii<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">L. parisiensis<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">L. sainthelensi<\/jats:named-content>, and<jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>sp. strain D5382. All patients except one asymptomatic carrier showed pneumonia, including one with concurrent bacteremia. Nine patients died, with this infection being the immediate cause of death in six. Twenty-seven patients had underlying hematologic malignancies. Twenty-three patients were leukopenic. Six patients were recipients of allogeneic hematopoietic stem cell transplant, with their infections caused by five<jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>species. Together, these results suggest that diverse<jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>species infect patients with cancer in the Houston area and its vicinity. The five cases of pneumonia due to<jats:named-content content-type=\"genus-species\">L. donaldsonii<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Legionella<\/jats:named-content>sp. D5382 are likely the first reports of human infection with these organisms.<\/jats:p>","DOI":"10.1128\/jcm.00380-15","type":"journal-article","created":{"date-parts":[[2015,4,30]],"date-time":"2015-04-30T02:21:46Z","timestamp":1430360506000},"page":"2180-2187","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Microbiological and Clinical Studies of Legionellosis in 33 Patients with Cancer"],"prefix":"10.1128","volume":"53","author":[{"given":"Xiang Y.","family":"Han","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ihegword","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott E.","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey J.","family":"Tarrand","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"El-Kweifi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712012972202"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-4-656"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1128\/9781555816728.ch45","volume-title":"Manual of clinical microbiology","author":"Edelstein PH","year":"2011","unstructured":"Edelstein PH. 2011. Legionella, p 770\u2013785. 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