{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:31:28Z","timestamp":1787941888113,"version":"build-2784847793"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In South Africa, serogroup B meningococcal disease is sporadic. The aim of this study was to characterize serogroup B strains causing invasive meningococcal disease (IMD) in South Africa from 2005 to 2008. Isolates, collected through a national, laboratory-based surveillance program for IMD, were characterized by multilocus sequence typing (MLST). Two thousand two hundred thirty-four cases were reported, of which 1,447 had viable isolates. Intermediate resistance to penicillin was observed in 2.8% (41\/1,447) of all strains. Serogroup B was the second most common serogroup (17%, 251\/1,447) and increased from 14% (58\/414) in 2005 to 25% (72\/290) in 2008 (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001); however, incidence remained stable during the study period (average incidence, 0.13\/100,000 population) (\n            <jats:italic>P<\/jats:italic>\n            = 0.54). Serogroup B was predominantly characterized by three clonal complexes, namely, ST-41\/44\/lineage 3, ST-32\/ET-5, and the new complex ST-4240\/6688, which accounted for 27% (65\/242), 23% (55\/242), and 16% (38\/242) of isolates, respectively. ST-4240\/6688 was more prevalent among young children (&lt;5 years) than other clonal complexes (27\/37 [73%] versus 108\/196 [55%];\n            <jats:italic>P<\/jats:italic>\n            = 0.04). In the most densely populated province of South Africa, Gauteng, the prevalence of ST-32\/ET-5 increased from 8% (2\/24) in 2005 to 38% (9\/24) in 2008 (\n            <jats:italic>P<\/jats:italic>\n            = 0.04). Capsular switching was observed in 8\/242 (3%) strains. The newly assigned clonal complex ST-4240\/6688 was more common in young children.\n          <\/jats:p>","DOI":"10.1128\/jcm.00401-12","type":"journal-article","created":{"date-parts":[[2012,5,17]],"date-time":"2012-05-17T17:07:32Z","timestamp":1337274452000},"page":"2577-2584","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Population Snapshot of Invasive Serogroup B Meningococci in South Africa from 2005 to 2008"],"prefix":"10.1128","volume":"50","author":[{"given":"Mignon","family":"du Plessis","sequence":"first","affiliation":[{"name":"Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa"},{"name":"School of Pathology, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Medical Research Council, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chivonne","family":"Moodley","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa"},{"name":"School of Pathology, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Medical Research Council, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kedibone M.","family":"Mothibeli","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa"},{"name":"School of Pathology, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Medical Research Council, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azola","family":"Fali","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa"},{"name":"Medical Research Council, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith P.","family":"Klugman","sequence":"additional","affiliation":[{"name":"School of Pathology, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Medical Research Council, South Africa"},{"name":"Hubert Department of Global Health, Rollins School of Public Health, and Division of Infectious Diseases, School of Medicine, Emory University, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"von Gottberg","sequence":"additional","affiliation":[{"name":"Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases (NICD) of the National Health Laboratory Service (NHLS), Johannesburg, South Africa"},{"name":"School of Pathology, University of the Witwatersrand, Johannesburg, South Africa"},{"name":"Medical Research Council, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2001.00722.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91961-S"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0264-410X(94)00037-N"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.13.4927"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.169.6.2781-2792.1987"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.55.6.1503-1512.1987"},{"key":"e_1_3_2_8_2","volume-title":"CLSI document M100-S18.","author":"CLSI","year":"2008","unstructured":"CLSI. 2008. 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