{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:04:03Z","timestamp":1772136243004,"version":"3.50.1"},"reference-count":34,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Eumycetoma is a debilitating, chronic, fungal infection that is endemic in India, Indonesia, and parts of Africa and South and Central America. It remains a neglected tropical disease in need of international recognition. Infections follow traumatic implantation of saprophytic fungi and frequently require radical surgery or amputation in the absence of appropriate treatment. Several fungal species can cause black-grain mycetomas, including\n            <jats:named-content content-type=\"genus-species\">Madurella<\/jats:named-content>\n            spp. (\n            <jats:named-content content-type=\"genus-species\">Sordariales<\/jats:named-content>\n            ),\n            <jats:named-content content-type=\"genus-species\">Falciformispora<\/jats:named-content>\n            spp.,\n            <jats:named-content content-type=\"genus-species\">Trematosphaeria grisea<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Biatriospora mackinnonii<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Pseudochaetosphaeronema larense<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">Medicopsis romeroi<\/jats:named-content>\n            (all\n            <jats:named-content content-type=\"genus-species\">Pleosporales<\/jats:named-content>\n            ). We performed phylogenetic analyses based on five loci on 31 isolates from two international culture collections to establish the taxonomic affiliations of fungi that had been isolated from cases of black-grain mycetoma and historically classified as\n            <jats:named-content content-type=\"genus-species\">Madurella grisea<\/jats:named-content>\n            . Although most strains were well resolved to species level and corresponded to known agents of eumycetoma, six independent isolates, which failed to produce conidia under any conditions tested, were only distantly related to existing members of the\n            <jats:named-content content-type=\"genus-species\">Pleosporales<\/jats:named-content>\n            . Five of the six isolates shared &gt;99% identity with each other and are described as\n            <jats:named-content content-type=\"genus-species\">Emarellia grisea<\/jats:named-content>\n            gen. nov. and sp. nov; the sixth isolate represents a sister species in this novel genus and is described as\n            <jats:named-content content-type=\"genus-species\">Emarellia paragrisea.<\/jats:named-content>\n            Several\n            <jats:named-content content-type=\"genus-species\">E. grisea<\/jats:named-content>\n            isolates were present in both United Kingdom and French culture collections and had been isolated independently over 6 decades from cases of imported eumycetoma. Four of the six isolates involved patients that had originated on the Indian subcontinent. All isolates were all susceptible\n            <jats:italic>in vitro<\/jats:italic>\n            to the azole antifungals, but had elevated MICs with caspofungin.\n          <\/jats:p>","DOI":"10.1128\/jcm.00477-16","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T04:09:52Z","timestamp":1460606992000},"page":"1738-1745","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Novel Taxa Associated with Human Fungal Black-Grain Mycetomas: Emarellia grisea gen. nov., sp. nov., and Emarellia paragrisea sp. nov"],"prefix":"10.1128","volume":"54","author":[{"given":"Andrew M.","family":"Borman","sequence":"first","affiliation":[{"name":"PHE Mycology Reference Laboratory, Bristol, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Desnos-Ollivier","sequence":"additional","affiliation":[{"name":"Institut Pasteur, National Reference Centre for Invasive Mycosis and Antifungals, Molecular Mycology Unit, CNRS URA3012, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin K.","family":"Campbell","sequence":"additional","affiliation":[{"name":"PHE Mycology Reference Laboratory, Bristol, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Bridge","sequence":"additional","affiliation":[{"name":"CABI Europe\u2013UK, Egham, Surrey, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Dannaoui","sequence":"additional","affiliation":[{"name":"Institut Pasteur, National Reference Centre for Invasive Mycosis and Antifungals, Molecular Mycology Unit, CNRS URA3012, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"PHE Mycology Reference Laboratory, Bristol, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","first-page":"237","article-title":"Mycetoma in prehispanic Mexico: review in the skeletical collection of Tlatilco culture","volume":"47","author":"Mansilla-Lory J","year":"2009","unstructured":"Mansilla-Lory J, Contreras-Lopez EA. 2009. 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