{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:26:34Z","timestamp":1791152794298,"version":"4.1.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Among patients with cirrhosis, infections caused by\n            <jats:italic>Escherichia coli<\/jats:italic>\n            organisms that translocate from the gut are a frequent and severe complication. One hundred ten\n            <jats:italic>E. coli<\/jats:italic>\n            isolates from 110 cirrhotic patients with spontaneous bacterial peritonitis and\/or spontaneous bacteremia were characterized for their phylogenetic group and virulence genotype (34 extraintestinal virulence factor genes). Genetic relatedness was investigated by enterobacterial repetitive intergenic consensus sequence type 2 (ERIC-2) PCR typing and multilocus sequence typing. Phylogenetic groups A, B1, B2, and D accounted for 24%, 4%, 48%, and 24% of the population, respectively. Overall, 68 distinct ERIC-2 profiles were encountered. Eleven clonal groups, represented by multiple isolates (2 to 11) from the same sequence type (ST) or sequence type complex, were identified. These clonal groups accounted for 54 (49%) isolates overall. Membership in one of these clonal groups was more frequent among B2 isolates than non-B2 isolates (67% versus 32%,\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.001). The most frequent sequence types were ST95 (\n            <jats:italic>n<\/jats:italic>\n            = 13) and ST73 (\n            <jats:italic>n<\/jats:italic>\n            = 8), followed by the ST14 and ST10 complexes (\n            <jats:italic>n<\/jats:italic>\n            = 7). ST131 and ST69 were represented by three isolates each. Clonal group-associated isolates exhibited a greater prevalence of 11 virulence genes, including\n            <jats:italic>pap<\/jats:italic>\n            elements, than the other isolates. However, no association between clonal groups and host factors, type of infection, or mortality was observed. In conclusion,\n            <jats:italic>E. coli<\/jats:italic>\n            isolates causing spontaneous bacterial peritonitis and bacteremia in cirrhotic patients are genetically diverse. However, approximately half of the isolates belong to familiar clonal groups and exhibit extensive virulence profiles that may be associated with greater invasive potential.\n          <\/jats:p>","DOI":"10.1128\/jcm.00516-10","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T02:51:58Z","timestamp":1275533518000},"page":"2709-2714","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":61,"title":["Genetic Diversity and Virulence Profiles of\n            <i>Escherichia coli<\/i>\n            Isolates Causing Spontaneous Bacterial Peritonitis and Bacteremia in Patients with Cirrhosis"],"prefix":"10.1128","volume":"48","author":[{"given":"Fre\u0301de\u0301ric","family":"Bert","sequence":"first","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Beaujon, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and Department of Medicine, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u0301ne\u0301dicte","family":"Ouattara","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Beaujon, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ve\u0301ronique","family":"Leflon-Guibout","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Beaujon, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Johnston","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center and Department of Medicine, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Marcon","sequence":"additional","affiliation":[{"name":"Service de Microbiologie, Ho\u0302pital Beaujon, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), Clichy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Valla","sequence":"additional","affiliation":[{"name":"Service d'He\u0301patologie, Ho\u0302pital Beaujon, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), Clichy, France"},{"name":"INSERM U 773, Centre de Recherche Biome\u0301dicale Bichat-Beaujon CRB3, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Moreau","sequence":"additional","affiliation":[{"name":"Service d'He\u0301patologie, Ho\u0302pital Beaujon, Assistance Publique-Ho\u0302pitaux de Paris (AP-HP), Clichy, France"},{"name":"INSERM U 773, Centre de Recherche Biome\u0301dicale 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