{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:59:01Z","timestamp":1792202341776,"version":"4.4.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Government of Papua New Guinea","award":["ICRAS 297\/1"],"award-info":[{"award-number":["ICRAS 297\/1"]}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1071269"],"award-info":[{"award-number":["1071269"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1013209"],"award-info":[{"award-number":["1013209"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The World Health Organization has recommended that testing for high-risk human papillomavirus (HPV) (hrHPV) infection be incorporated into cervical screening programs in all settings worldwide. In many high-burden, low-income countries, it will not be feasible to achieve high cervical screening coverage using hrHPV assays that require clinician-collected samples. We conducted the first evaluation of self-collected vaginal specimens compared with clinician-collected cervical specimens for the detection of hrHPV infection using the Xpert HPV test. Women aged 30 to 54 years attending two well-woman clinics in Papua New Guinea were invited to participate and provided self-collected vaginal and clinician-collected cervical cytobrush specimens. Both specimen types were tested at the point of care by using the Xpert HPV test. Women were given their cervical test result the same day. Those with a positive hrHPV test and positive examination upon visual inspection of the cervix with acetic acid were offered same-day cervical cryotherapy. A total of 1,005 women were enrolled, with 124 (12.3%; 95% confidence interval [CI], 10.3%, 14.4%) being positive for any hrHPV infection. There was a 99.4% overall percent agreement (OPA) between vaginal and cervical tests for HPV-16 (95% CI, 98.9%, 99.9%), a 98.5% OPA for HPV-18\/45 (95% CI, 97.7%, 99.3%), a 94.4% OPA for other hrHPV infections (95% CI, 92.9%, 95.9%), and a 93.4% OPA for all hrHPV types combined (95% CI, 91.8%, 95.0%). Self-collected vaginal specimens had excellent agreement with clinician-collected cervical specimens for the detection of hrHPV infection using the Xpert HPV test. This approach provides for the first time an opportunity to incorporate point-of-care hrHPV testing into clinical cervical screening algorithms in high-burden, low-income settings.<\/jats:p>","DOI":"10.1128\/jcm.00529-16","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T00:09:52Z","timestamp":1460592592000},"page":"1734-1737","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["Field Evaluation of Xpert HPV Point-of-Care Test for Detection of Human Papillomavirus Infection by Use of Self-Collected Vaginal and Clinician-Collected Cervical Specimens"],"prefix":"10.1128","volume":"54","author":[{"given":"P.","family":"Toliman","sequence":"first","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Badman","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gabuzzi","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Silim","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Forereme","sequence":"additional","affiliation":[{"name":"Eastern Highlands Provincial Hospital, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kumbia","sequence":"additional","affiliation":[{"name":"Eastern Highlands Provincial Hospital, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kombuk","sequence":"additional","affiliation":[{"name":"Mt. Hagen General Hospital, Western Highlands Province, Mt. Hagen, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Kombati","sequence":"additional","affiliation":[{"name":"Mt. Hagen General Hospital, Western Highlands Province, Mt. Hagen, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Allan","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Munnull","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ryan","sequence":"additional","affiliation":[{"name":"The Burnet Institute, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M.","family":"Vallely","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"},{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kelly-Hanku","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"},{"name":"School of Public Health and Community Medicine, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Wand","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. D. L.","family":"Mola","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, School of Medicine and Health Sciences, University of Papua New Guinea, National Capital District, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Guy","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Siba","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Kaldor","sequence":"additional","affiliation":[{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, The Royal Women's Hospital, Parkville, Victoria, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. J.","family":"Vallely","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea"},{"name":"The Kirby Institute, UNSW Australia, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-10-200005160-00009"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00176-14"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a1754"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808516"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70296-0"},{"key":"e_1_3_2_7_2","volume-title":"Abstr Prev Cervical Cancer 2015 Conf","author":"Canfell K","year":"2015","unstructured":"Canfell K. 2015. Compass\u2014a randomised controlled trial of HPV screening in Australia, abstr 8. Abstr Prev Cervical Cancer 2015 Conf, Melbourne, Australia, 20 to 22 February 2015."},{"key":"e_1_3_2_8_2","volume-title":"National Cervical Screening Program","author":"Australian Government Department of Health","year":"2014","unstructured":"Australian Government Department of Health. 2014. National Cervical Screening Program. Overview of the renewal. Australian Government Department of Health, Canberra, ACT, Australia. http:\/\/www.cancerscreening.gov.au\/internet\/screening\/publishing.nsf\/Content\/overview-of-the-renewal. Accessed 14 January 2015."},{"key":"e_1_3_2_9_2","volume-title":"WHO guidelines for screening and treatment of precancerous lesions for cervical cancer prevention","author":"WHO","year":"2013","unstructured":"WHO. 2013. WHO guidelines for screening and treatment of precancerous lesions for cervical cancer prevention. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP4Q0NSDHWIZGU"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00806-13"},{"key":"e_1_3_2_12_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_13_2","volume-title":"GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012","author":"WHO, IARC","year":"2015","unstructured":"WHO, IARC. 2015. GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012. http:\/\/globocan.iarc.fr\/Pages\/fact_sheets_population.aspx. World Health Organization, Geneva, Switzerland."},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_3_2_15_2","first-page":"83","article-title":"Achieving control of cervical cancer in Papua New Guinea: what are the research and program priorities?","volume":"54","author":"Vallely A","year":"2011","unstructured":"Vallely A, Mola GD, Kaldor JM. 2011. Achieving control of cervical cancer in Papua New Guinea: what are the research and program priorities? P N G Med J 54:83\u201390.","journal-title":"P N G Med J"},{"key":"e_1_3_2_16_2","unstructured":"Reference deleted."},{"key":"e_1_3_2_17_2","volume-title":"Statistical guidance on reporting results from studies evaluating diagnostic tests","author":"FDA","year":"2007","unstructured":"FDA. 2007. Statistical guidance on reporting results from studies evaluating diagnostic tests. Food and Drug Administration, US Department of Health and Human Services, Rockville, MD."},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70570-9"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00529-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00529-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T04:46:19Z","timestamp":1646455579000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00529-16"}},"subtitle":[],"editor":[{"given":"D. J.","family":"Diekema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":18,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1128\/JCM.00529-16"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00529-16","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726286699.793529268","asserted-by":"object"}]},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"2016-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}