{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:35:47Z","timestamp":1789583747774,"version":"build-2803163510"},"reference-count":52,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of\n            <jats:named-content content-type=\"genus-species\">Fonsecaea<\/jats:named-content>\n            in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU),\n            <jats:italic>BT2<\/jats:italic>\n            , and\n            <jats:italic>CDC42<\/jats:italic>\n            genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain.\n          <\/jats:p>","DOI":"10.1128\/jcm.00637-15","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T02:36:58Z","timestamp":1434595018000},"page":"2674-2685","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":66,"title":["Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis"],"prefix":"10.1128","volume":"53","author":[{"given":"Concei\u00e7\u00e3o M. P. S.","family":"de Azevedo","sequence":"first","affiliation":[{"name":"Department of Medicine, Federal University of Maranh\u00e3o, Brazil, S\u00e3o Luis, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata R.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania A.","family":"Vicente","sequence":"additional","affiliation":[{"name":"Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W. C. L.","family":"Santos","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases Emilio Ribas, S\u00e3o Paulo, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirlei G.","family":"Marques","sequence":"additional","affiliation":[{"name":"University Hospital of Federal University of Maranh\u00e3o and Cedro Laboratories Maranh\u00e3o, S\u00e3o Luis, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana M. F.","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E. W.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimunda R.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Maranh\u00e3o, Brazil, S\u00e3o Luis, MA, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1vio","family":"Queiroz-Telles","sequence":"additional","affiliation":[{"name":"Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba, PR, Brazil"},{"name":"Clinical Hospital of the Federal University of Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Sybren","family":"de Hoog","sequence":"additional","affiliation":[{"name":"Microbiology, Parasitology and Pathology Post-graduation Program, Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba, PR, Brazil"},{"name":"Centraalbureau voor Schimmelcultures KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802538001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780410001661464"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2001.00613.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652004000100006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13225-013-0246-5"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3114\/sim.2007.58.08"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802468209"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2013.08.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm.45.105"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780802527178"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693780903503081"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-006-9080-z"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3114\/sim.2008.61.18"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(09)70131-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0507.2003.00956.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652003000400008"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500220373"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.5414\/NPP26021"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693780903471081"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1703.100555"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006957415346"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.3114\/sim.2008.61.14"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041512"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2009.10.002"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2010.01995.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01655-09"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13225-012-0194-5"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1998.tb00321.x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681219580000651"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/aem.61.4.1323-1330.1995"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst197"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbn013"},{"key":"e_1_3_3_34_2","volume-title":"PAUP*. Phylogenetic analysis using parsimony","author":"Swofford D","year":"2003","unstructured":"Swofford D. 2003. PAUP*. Phylogenetic analysis using parsimony. Version 4. Sinauer Associates, Sunderland, MA."},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3767\/003158511X614258"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/sysbio\/42.2.182"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00065-12"},{"key":"e_1_3_3_38_2","first-page":"491","article-title":"Cerebral phaeohyphomycosis complicated with brain abscess: a case report","volume":"55","author":"Lirng JF","year":"1995","unstructured":"Lirng JF, Tien RD, Osumi AK, Madden JF, McLendon RP, Sexton D. 1995. Cerebral phaeohyphomycosis complicated with brain abscess: a case report. Zhonghua Yi Xue Za Zhi (Taipei) 55:491\u2013495.","journal-title":"Zhonghua Yi Xue Za Zhi (Taipei)"},{"key":"e_1_3_3_39_2","first-page":"176","article-title":"Primary cerebral infections by melanized fungi: a review","volume":"43","author":"Horr\u00e9 R","year":"1999","unstructured":"Horr\u00e9 R, de Hoog GS. 1999. Primary cerebral infections by melanized fungi: a review. Stud Mycol 43:176\u2013193. http:\/\/www.fungalbiodiversitycentre.com\/publications\/1043\/content\/pdf\/176-193.pdf.","journal-title":"Stud Mycol"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1053\/jfms.2002.0183"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1439-0442.2003.00501.x"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/02681219380000391"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.3.708-715.1998"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.5.1159-1162.2000"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.38.5.1965-1966.2000"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-013-9632-5"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2006.05.007"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.38.s1.243.250"},{"key":"e_1_3_3_49_2","first-page":"475","article-title":"Cerebral mycosis from Cladosporium tricho\u00efdes in a native of the Belgian Congo","volume":"34","author":"Lucasse C","year":"1954","unstructured":"Lucasse C, Chardome J, Magis P. 1954. Cerebral mycosis from Cladosporium tricho\u00efdes in a native of the Belgian Congo. Ann Soc Belg Med Trop 34:475\u2013478. (In French.)","journal-title":"Ann Soc Belg Med Trop"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1975.tb00074.x"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.59.1.0158"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2011.06.004"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.funbio.2011.06.007"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00637-15","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00637-15","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T12:21:28Z","timestamp":1646482888000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00637-15"}},"subtitle":[],"editor":[{"given":"D. W.","family":"Warnock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1128\/JCM.00637-15"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00637-15","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"2015-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-06-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}