{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:14:33Z","timestamp":1723072473782},"reference-count":24,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"NIH\/NIAID","award":["1R01AI099727"],"award-info":[{"award-number":["1R01AI099727"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Combining the detection of syphilis and HIV antibodies into one point-of-care test integrates syphilis screening into already existing HIV screening programs, which may be particularly beneficial in settings such as antenatal care. Using the INSTI Multiplex downward-flow immunoassay, we tested 200 stored serum samples from high-risk patients enrolled in a longitudinal study on HIV infection and syphilis in Peruvian men who have sex with men and transgender women. This rapid assay detected HIV and\n            <jats:named-content content-type=\"genus-species\">Treponema pallidum<\/jats:named-content>\n            serum antibodies with sensitivities of 100% (95% confidence interval [CI], 95.9% to 100%) and 87.4% (95% CI, 81.4% to 92.0%), respectively, and specificities of 95.5% (95% CI, 89.9% to 98.5%) and 97.0% (95% CI, 84.2% to 99.9%), respectively (\n            <jats:italic>n<\/jats:italic>\n            = 200). The sensitivity for syphilis antibody detection was higher in patients with a rapid plasma reagin titer of \u22651:8 (97.3%) than in those with a titer of \u22641:4 (90%) or a nonreactive titer (66.7%).\n          <\/jats:p>","DOI":"10.1128\/jcm.00637-16","type":"journal-article","created":{"date-parts":[[2016,5,5]],"date-time":"2016-05-05T04:20:23Z","timestamp":1462422023000},"page":"1922-1924","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Laboratory Evaluation of a Point-of-Care Downward-Flow Assay for Simultaneous Detection of Antibodies to Treponema pallidum and Human Immunodeficiency Virus"],"prefix":"10.1128","volume":"54","author":[{"given":"S.","family":"Herbst de Cortina","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Bristow","sequence":"additional","affiliation":[{"name":"Division of Global Public Health, Department of Medicine, University of California San Diego, La Jolla, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Vargas","sequence":"additional","affiliation":[{"name":"Unit of Health, Sexuality, and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Miraflores, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Perez","sequence":"additional","affiliation":[{"name":"Unit of Health, Sexuality, and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Miraflores, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. A.","family":"Konda","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA"},{"name":"Unit of Health, Sexuality, and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Miraflores, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. F.","family":"Caceres","sequence":"additional","affiliation":[{"name":"Unit of Health, Sexuality, and Human Development, and Laboratory of Sexual Health, Universidad Peruana Cayetano Heredia, Miraflores, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Klausner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA"},{"name":"Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143304"},{"key":"e_1_3_2_3_2","volume-title":"HIV\/AIDS fact sheet","author":"World Health Organization","unstructured":"World Health Organization. 26 February 2016, accession date. HIV\/AIDS fact sheet. World Health Organization, Geneva, Switzerland. http:\/\/www.who.int\/mediacentre\/factsheets\/fs360\/en\/."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/513427"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052367"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/164797"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/819593"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2014.10.007"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.08.024"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12061"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2010.12.022"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011581"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-13-426"},{"key":"e_1_3_2_14_2","first-page":"402","article-title":"Economic and programmatic aspects of congenital syphilis prevention","volume":"82","author":"Schmid G","year":"2004","unstructured":"Schmid G. 2004. Economic and programmatic aspects of congenital syphilis prevention. Bull World Health Organ 82:402\u2013409.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofu015"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2015-052326"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000387"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02763-14"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112190"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02468-14"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-746"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-007371"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.04.004"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03152-15"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091504"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00637-16","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00637-16","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T09:47:58Z","timestamp":1646473678000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00637-16"}},"subtitle":[],"editor":[{"given":"A. 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