{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:26:38Z","timestamp":1792099598008,"version":"4.4.0"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI139369"],"award-info":[{"award-number":["AI139369"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["AI146771"],"award-info":[{"award-number":["AI146771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015158","name":"Fondren Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015158","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2020,8,24]]},"abstract":"<jats:p>\n                    Resistance to macrolide antibiotics is a global concern in the treatment of\n                    <jats:named-content content-type=\"genus-species\">Streptococcus pyogenes<\/jats:named-content>\n                    (group A\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    [GAS]) infections. In Iceland, since the detection of the first macrolide-resistant isolate in 1998, three epidemic waves of macrolide-resistant GAS infections have occurred, with peaks in 1999, 2004, and 2008. We conducted whole-genome sequencing of all 1,575 available GAS macrolide-resistant clinical isolates of all infection types collected at the national reference laboratory in Reykjavik, Iceland, from 1998 to 2016.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00638-20","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T09:31:19Z","timestamp":1591695079000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":39,"title":["Population Genomic Molecular Epidemiological Study of Macrolide-Resistant Streptococcus pyogenes in Iceland, 1995 to 2016: Identification of a Large Clonal Population with a\n                    <i>pbp2x<\/i>\n                    Mutation Conferring Reduced\n                    <i>In Vitro<\/i>\n                    \u03b2-Lactam Susceptibility"],"prefix":"10.1128","volume":"58","author":[{"given":"Sara B.","family":"Southon","sequence":"first","affiliation":[{"name":"Department of Clinical Microbiology, Landspitali\u2014The National University Hospital of Iceland, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-0185","authenticated-orcid":false,"given":"Stephen B.","family":"Beres","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Disease Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-7832","authenticated-orcid":false,"given":"Priyanka","family":"Kachroo","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Disease Research, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and 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