{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:57:18Z","timestamp":1793444238612,"version":"4.5.0"},"reference-count":39,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Escherichia coli<\/jats:named-content>\n            is the most common cause of urinary tract infections (UTIs).\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            genes epidemiologically associated with UTIs are potentially valuable in developing strategies for treating and\/or preventing such infections as well as differentiating uropathogenic\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            from nonuropathogenic\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            . To identify\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            genes associated with UTIs in humans, we combined microarray-based and PCR-based analyses to investigate different\n            <jats:named-content content-type=\"genus-species\">E. coli<\/jats:named-content>\n            source groups derived from feces of healthy humans and from patients with cystitis, pyelonephritis, or urosepsis. The\n            <jats:italic>cjrABC-senB<\/jats:italic>\n            gene cluster,\n            <jats:italic>sivH<\/jats:italic>\n            ,\n            <jats:italic>sisA<\/jats:italic>\n            ,\n            <jats:italic>sisB<\/jats:italic>\n            ,\n            <jats:italic>eco274<\/jats:italic>\n            , and\n            <jats:italic>fbpB<\/jats:italic>\n            , were identified to be associated with UTIs. Of these,\n            <jats:italic>cjrABC-senB<\/jats:italic>\n            ,\n            <jats:italic>sisA<\/jats:italic>\n            ,\n            <jats:italic>sisB<\/jats:italic>\n            , and\n            <jats:italic>fbpB<\/jats:italic>\n            are known to be involved in urovirulence in the mouse model of ascending UTI. Our results provide evidence to support their roles as urovirulence factors in human UTIs. In addition, the newly identified UTI-associated genes were mainly found in members of phylogenetic groups B2 and\/or D.\n          <\/jats:p>","DOI":"10.1128\/jcm.00640-11","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T02:59:33Z","timestamp":1320980373000},"page":"449-456","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":54,"title":["Identification of Escherichia coli Genes Associated with Urinary Tract Infections"],"prefix":"10.1128","volume":"50","author":[{"given":"Bin-Hsu","family":"Mao","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Fu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Scaria","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ching","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, National Cheng Kung University Medical College, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Wei","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, China Medical University Hospital, Taichung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Tien","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, China Medical University Hospital, Taichung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Jong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University Medical College, Tainan City, Taiwan"},{"name":"Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chung","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Cheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Chin","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Microbiology and Public Health, School of Veterinary Medicine, National Chung Hsing University, Taichung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Man","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Biological Science and Technology, China Medical University, Taichung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hao","family":"Teng","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan City, Taiwan"},{"name":"Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000586"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603038103"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02885-05"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600938103"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.10.4555-4558.2000"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01260-09"},{"key":"e_1_3_3_8_2","first-page":"1853","article-title":"Highly pathogenic strains of Escherichia coli revealed by the distinct electrophoretic patterns of carboxylesterase B","volume":"132","author":"Goullet P","year":"1986","unstructured":"GoulletP PicardB . 1986. Highly pathogenic strains of Escherichia coli revealed by the distinct electrophoretic patterns of carboxylesterase B. J. Gen. Microbiol. 132:1853\u20131858.","journal-title":"J. Gen. Microbiol."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(69)90478-4"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001187"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1462-5822.2003.00320.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2317-2327.2006"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/317656"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.1.337-345.2003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5363-5374.2001"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2005.07.005"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/315217"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.2.629-640.2003"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm101011y"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5312.607"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01717-08"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01744-06"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00779-09"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsle.2005.08.028"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/35101614"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01449.x"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.12.4721-4728.1995"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.4.1495-1501.2006"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2425-2434.2005"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/35054089"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.546-553.1999"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2005.03.014"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.13.3958-3966.2001"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2009.09.007"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000344"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65644-3"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01448.x"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02708.x"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252529799"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1086\/505429"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00640-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00640-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:03:05Z","timestamp":1646478185000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00640-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1128\/JCM.00640-11"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00640-11","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}