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In tropical and subtropical areas, the infection is relatively common and associated with trauma or chronic eye diseases. However, in recent years, an increased incidence has been reported in temperate climate regions. At the German National Reference Center, we have observed a steady increase in case numbers since 2014. Here, we present the first German case series of eye infections with\n                    <jats:named-content content-type=\"genus-species\">Fusarium<\/jats:named-content>\n                    species. We identified\n                    <jats:named-content content-type=\"genus-species\">Fusarium<\/jats:named-content>\n                    isolates from the eye or eye-related material from 22 patients in 2014 and 2015. Thirteen isolates belonged to the\n                    <jats:named-content content-type=\"genus-species\">Fusarium solani<\/jats:named-content>\n                    species complex (FSSC), 6 isolates belonged to the\n                    <jats:named-content content-type=\"genus-species\">Fusarium oxysporum<\/jats:named-content>\n                    species complex (FOSC), and three isolates belonged to the\n                    <jats:named-content content-type=\"genus-species\">Fusarium fujikuroi<\/jats:named-content>\n                    species complex (FFSC). FSSC was isolated in 13 of 15 (85%) definite infections and FOSC in 3 of 4 (75%) definite contaminations. Furthermore, diagnosis from contact lens swabs or a culture of contact lens solution turned out to be highly unreliable. FSSC isolates differed from FOSC and FFSC by a distinctly higher MIC for terbinafine. Outcome was often adverse, with 10 patients requiring keratoplasty or enucleation. The use of natamycin as the most effective agent against keratitis caused by filamentous fungi was rare in Germany, possibly due to restricted availability. Keratitis caused by\n                    <jats:named-content content-type=\"genus-species\">Fusarium<\/jats:named-content>\n                    spp. (usually FSSC) appears to be a relevant clinical problem in Germany, with the use of contact lenses as the predominant risk factor. Its outcome is often adverse.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00649-17","type":"journal-article","created":{"date-parts":[[2017,7,26]],"date-time":"2017-07-26T20:40:26Z","timestamp":1501101626000},"page":"2983-2995","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":84,"title":["Fusarium Keratitis in Germany"],"prefix":"10.1128","volume":"55","author":[{"given":"Grit","family":"Walther","sequence":"first","affiliation":[{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Stasch","sequence":"additional","affiliation":[{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Kaerger","sequence":"additional","affiliation":[{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Hamprecht","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Hygiene, University Hospital, Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Roth","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany"},{"name":"Department I of Internal Medicine, Clinical Trials Centre Cologne (ZKS K\u00f6ln), Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Geerling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Heinrich-Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin R.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology and Hospital Hygiene, University Hospital, Heinrich-Heine University, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Kurzai","sequence":"additional","affiliation":[{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Jena, Germany"},{"name":"University of W\u00fcrzburg, Institute for Hygiene and Microbiology, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"von Lilienfeld-Toal","sequence":"additional","affiliation":[{"name":"National Reference Center for Invasive Fungal Infections (NRZMyk), Leibniz Institute for Natural Product Research and Infection Biology, Hans Kn\u00f6ll Institute, Jena, Germany"},{"name":"University Hospital Jena, Department of Haematology and Medical Oncology, Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33229-X"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-013-9721-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-016-0303-z"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-014-9961-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2014.06.047"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12440"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-306485"},{"key":"e_1_3_2_9_2","first-page":"S116","article-title":"Corneal ulcer leading to evisceration or enucleation in a tertiary eye care center in Thailand: clinical and microbiological characteristics","volume":"99","author":"Hongyok T","year":"2016","unstructured":"Hongyok T Leelaprute W . 2016. 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Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics, p 315\u2013322. InInnisMAGelfandDHSninskyJJWhiteTJ (ed), PCR protocols: a guide to methods and applications. 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