{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:37:17Z","timestamp":1792028237373,"version":"4.4.0"},"reference-count":51,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>is frequently associated with localized aggressive periodontitis (LAP); however, longitudinal cohort studies relating<jats:italic>A. actinomycetemcomitans<\/jats:italic>to initiation of LAP have not been reported. A periodontal assessment was performed on 1,075 primarily African-American and Hispanic schoolchildren, ages 11 to 17 years. Samples were taken from each child for<jats:italic>A. actinomycetemcomitans<\/jats:italic>. A cohort of 96 students was established that included a test group of 38<jats:italic>A. actinomycetemcomitans<\/jats:italic>-positive students (36 periodontally healthy and 2 with periodontal pockets) and 58 healthy<jats:italic>A. actinomycetemcomitans<\/jats:italic>-negative controls. All clinical and microbiological procedures were repeated at 6-month intervals. Bitewing radiographs were taken annually for definitive diagnosis of LAP. At the initial examination, clinical probing attachment measurements indicated that 1.2% of students had LAP, while 13.7% carried<jats:italic>A. actinomycetemcomitans<\/jats:italic>, including 16.7% of African-American and 11% of Hispanic students (<jats:italic>P<\/jats:italic>= 0.001, chi-square test).<jats:italic>A. actinomycetemcomitans<\/jats:italic>serotypes a, b, and c were equally distributed among African-Americans; Hispanic students harbored predominantly serotype c (<jats:italic>P<\/jats:italic>= 0.05, chi-square test). In the longitudinal phase, survival analysis was performed to determine whether<jats:italic>A. actinomycetemcomitans<\/jats:italic>-positive as compared to<jats:italic>A. actinomycetemcomitans<\/jats:italic>-negative students remained healthy (\u201csurvived\u201d) or progressed to disease with attachment loss of &gt;2 mm or bone loss (failed to \u201csurvive\u201d). Students without<jats:italic>A. actinomycetemcomitans<\/jats:italic>at baseline had a significantly greater chance to remain healthy (survive) compared to the<jats:italic>A. actinomycetemcomitans<\/jats:italic>-positive test group (<jats:italic>P<\/jats:italic>= 0.0001). Eight of 38<jats:italic>A. actinomycetemcomitans<\/jats:italic>-positive and none of 58<jats:italic>A. actinomycetemcomitans<\/jats:italic>-negative students showed bone loss (<jats:italic>P<\/jats:italic>= 0.01).<jats:italic>A. actinomycetemcomitans<\/jats:italic>serotype did not appear to influence survival. These findings suggest that detection of<jats:italic>A. actinomycetemcomitans<\/jats:italic>in periodontally healthy children can serve as a risk marker for initiation of LAP.<\/jats:p>","DOI":"10.1128\/jcm.00653-07","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T01:25:01Z","timestamp":1192670701000},"page":"3859-3869","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":252,"title":["<i>Aggregatibacter actinomycetemcomitans<\/i>and Its Relationship to Initiation of Localized Aggressive Periodontitis: Longitudinal Cohort Study of Initially Healthy Adolescents"],"prefix":"10.1128","volume":"45","author":[{"given":"Daniel H.","family":"Fine","sequence":"first","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Furgang","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Fairlie","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ferrandiz","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cebile","family":"Nasri","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"McKiernan","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gunsolley","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Virginia Commonwealth University, Richmond, Virginia 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.6.370"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.290110.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1987.58.4.224"},{"key":"e_1_3_2_5_2","first-page":"333","volume":"4","year":"1978","unstructured":"Baehni, P., C. C. Tsai, N. S. Taichman, and W. McArthur. 1978. Interaction of inflammatory cells and oral microorganisms. J. Periodontol. Res.4:333-348.","journal-title":"J. Periodontol. Res."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1971.42.8.516"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1990.tb01106.x"},{"key":"e_1_3_2_8_2","first-page":"312","volume":"68","year":"1989","unstructured":"Bogert, M., P. Berthold, V. Brightman, R. Craig, J. DiRienzo, C.-H. Lai, E. Lally, J. Oler, T. Rams, B. Shenker, J. Slots, N. Taichman, and R. Tisot. 1989. Longtudinal study of LJP families\u2014two year surveillance. J. Dent. Res.68(Special issue):312.","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.10.968"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.9.998"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-051X.1995.tb01766.x","volume":"22","year":"1995","unstructured":"Clerehugh, V., H. V. Worthington, M. A. Lennon, and R. Chandler. 1995. Site progression of loss of attachment over 5 years in 14- to 19-year-old adolescents. J. Clin. Periodontol.22:15-21.","journal-title":"J. Clin. Periodontol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","volume":"34","year":"1972","unstructured":"Cox, D. R. 1972. Regression models and life-tables. J. Royal Stat. Soc.34:187-220.","journal-title":"J. Royal Stat. Soc."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028006524.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302X.2002.170301.x"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.1996.tb00054.x"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.616"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.624"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.4.1947-1953.2005"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1993.tb00554.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1984.tb01331.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.912"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1554"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.12.3037-3042.1997"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301006"},{"key":"e_1_3_2_25_2","first-page":"113","volume":"102","year":"1994","unstructured":"Holtta, P., S. Alaluusua, M. Saarela, and S. Asikainen. 1994. Isolation frequency and serotype distribution of mutans streptococci and Actinobacillus actinomycetemcomitans, and clinical periodontal status in Finnish and Vietnamese children. J. Dent. Res.102:113-119.","journal-title":"J. Dent. Res."},{"key":"e_1_3_2_26_2","first-page":"457","volume":"53","year":"1972","unstructured":"Kaplan, E. L., and P. Meier. 1972. Nonparametric estimation from incomplete observation. J. Am. Stat. Assoc.53:457-481.","journal-title":"J. Am. Stat. Assoc."},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5375-5384.2001"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1181-1187.2002"},{"key":"e_1_3_2_29_2","unstructured":"Clonal basis of bacterial virulence 1998"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.5.1465-1469.1989"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92431-5"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1998.tb01947.x"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1991.62.10.608"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1992.tb00586.x"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.1998.tb00701.x"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.360208.x"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.7.373"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvh154"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0722.2002.21361.x"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1994.tb00745.x"},{"key":"e_1_3_2_41_2","unstructured":"Oral health in America: a report of the Surgeon General 2000"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1237223100"},{"key":"e_1_3_2_43_2","unstructured":"Pocket formation: an hypothesis 1980 vol. II"},{"key":"e_1_3_2_44_2","first-page":"1","volume":"84","year":"1976","unstructured":"Slots, J. 1976. The predominant cultivable organisms in juvenile periodontitis. Scand. J. Dent. Res.84:1-10.","journal-title":"Scand. J. Dent. Res."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.29.3.1013-1020.1980"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00107.x"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.66.10.5008-5019.1998"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0810-5"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02415.x"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00805.x"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02020-06"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1983.54.12.707"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00653-07","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00653-07","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T18:45:43Z","timestamp":1737485143000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00653-07"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1128\/JCM.00653-07"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00653-07","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"2007-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}