{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:44:54Z","timestamp":1761155094898},"reference-count":21,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Antigen sequence typing (ST) of FetA is part of the molecular typing scheme of<jats:italic>Neisseria meningitidis<\/jats:italic>. Among invasive meningococcal isolates from 2,201 patients in Germany, we identified 11 strains lacking the<jats:italic>fetA<\/jats:italic>gene because of deletions mediated by repeat arrays flanking the gene, i.e., Correia elements, repeat sequence 13 (RS13), and duplicated RS3. Geographic mapping and multilocus ST of invasive isolates revealed that<jats:italic>fetA<\/jats:italic>deletion was a sporadic event without genetic fixation. Among 821 carrier strains, 12 strains lacked<jats:italic>fetA<\/jats:italic>, suggesting that<jats:italic>fetA<\/jats:italic>is maintained during asymptomatic carriage. Interestingly, most of these isolates belonged to the multilocus ST-35 clonal complex (cc). ST-35 cc strains and the recently published ST-192 strains from Burkina Faso may benefit from loss of<jats:italic>fetA<\/jats:italic>, but their infrequent occurrence among invasive isolates currently does not affect<jats:italic>fetA<\/jats:italic>antigen ST.<\/jats:p>","DOI":"10.1128\/jcm.00696-07","type":"journal-article","created":{"date-parts":[[2007,7,12]],"date-time":"2007-07-12T01:04:51Z","timestamp":1184202291000},"page":"2960-2964","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Deletion of the Meningococcal<i>fetA<\/i>Gene Used for Antigen Sequence Typing of Invasive and Commensal Isolates from Germany: Frequencies and Mechanisms"],"prefix":"10.1128","volume":"45","author":[{"given":"Heike","family":"Claus","sequence":"first","affiliation":[{"name":"University of Wu\u0308rzburg, Institute for Hygiene and Microbiology, National Reference Centre for Meningococci, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Elias","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg, Institute for Hygiene and Microbiology, National Reference Centre for Meningococci, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Meinhardt","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg, Institute for Hygiene and Microbiology, National Reference Centre for Meningococci, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Frosch","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg, Institute for Hygiene and Microbiology, National Reference Centre for Meningococci, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Vogel","sequence":"additional","affiliation":[{"name":"University of Wu\u0308rzburg, Institute for Hygiene and Microbiology, National Reference Centre for Meningococci, Wu\u0308rzburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030023"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-2958.2000.01873.x","volume":"36","year":"2000","unstructured":"Carson, S. 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