{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:01:03Z","timestamp":1791194463120,"version":"4.1.0"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:named-content content-type=\"genus-species\">Aggregatibacter actinomycetemcomitans<\/jats:named-content>-induced localized aggressive periodontitis (LAP) in African-American adolescents has been documented but is poorly understood. Two thousand fifty-eight adolescents aged 11 to 17 years were screened for their periodontal status and the presence of<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>in their oral cavity. Seventy-one<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>-negative and 63<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>-positive periodontally healthy subjects were enrolled, sampled, examined, and radiographed yearly for 3 years. Gingival and periodontal pocket depth and attachment levels were recorded. Disease presentation was characterized by bone loss (BL). Subgingival sites were sampled every 6 months to assess (i) the role of<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>in BL and (ii) the association of<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>and other microbes in their relationships to BL. Sixteen of 63 subjects with<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>developed BL (the other 47 subjects with<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>had no BL). No<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>-negative subjects developed BL. Human oral microbe identification microarray (HOMIM) was used for subgingival microbial assessment. On a subject level, pooled data from<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>-positive subjects who remained healthy had higher prevalences of<jats:named-content content-type=\"genus-species\">Streptococcus<\/jats:named-content>and<jats:named-content content-type=\"genus-species\">Actinomyces<\/jats:named-content>species, while<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>-positive subjects with BL had higher prevalences of<jats:named-content content-type=\"genus-species\">Parvimonas micra<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Filifactor alocis<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>, and<jats:named-content content-type=\"genus-species\">Peptostreptococcus<\/jats:named-content>sp. human oral taxon 113 (HOT-113). At vulnerable sites,<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">Streptococcus parasanguinis<\/jats:named-content>, and<jats:named-content content-type=\"genus-species\">F. alocis<\/jats:named-content>levels were elevated prior to BL. In cases where the three-organism consortium (versus<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>alone) was detected, the specificity for detecting sites of future BL increased from 62% to 99%, with a sensitivity of 89%. We conclude that detecting the presence of<jats:named-content content-type=\"genus-species\">A. actinomycetemcomitans<\/jats:named-content>,<jats:named-content content-type=\"genus-species\">S. parasanguinis<\/jats:named-content>, and<jats:named-content content-type=\"genus-species\">F. alocis<\/jats:named-content>together indicates sites of future BL in LAP. A synergistic interaction of this consortium in LAP causation is possible and is the subject of ongoing research.<\/jats:p>","DOI":"10.1128\/jcm.00729-13","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T04:32:17Z","timestamp":1371702737000},"page":"2850-2861","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":129,"title":["A Consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis Is Present in Sites Prior to Bone Loss in a Longitudinal Study of Localized Aggressive Periodontitis"],"prefix":"10.1128","volume":"51","author":[{"given":"Daniel H.","family":"Fine","sequence":"first","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Fairlie","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Tischio-Bereski","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Ferrendiz","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Furgang","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce J.","family":"Paster","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Forsyth Institute, Cambridge, Massachusetts, USA"},{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floyd E.","family":"Dewhirst","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Forsyth Institute, Cambridge, Massachusetts, USA"},{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1976.47.7.373"},{"key":"e_1_3_3_3_2","first-page":"1","article-title":"The predominant cultivable organisms in juvenile periodontitis","volume":"84","author":"Slots J","year":"1976","unstructured":"SlotsJ. 1976. 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