{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:47:26Z","timestamp":1791010046422,"version":"4.1.0"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Early evaluation of treatment efficacy in invasive aspergillosis (IA), a leading cause of morbidity and mortality in hematological patients, remains a challenge. We conducted a prospective study to evaluate the performance of different markers in predicting the outcome of patients with IA. Both clinical and biological criteria were assessed 7, 14, 21, and 45 days after inclusion in the study, and mortality was assessed at day 60. The association between baseline data and their evolution and the day 45 response to treatment was analyzed. A total of 57 patients (4 with proven, 44 with probable, and 9 with possible aspergillosis according to the revised EORTC\/MSG [European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and National Institute of Allergy and Infectious Diseases Mycoses Study Group] definitions) were included. At day 45, 30 patients (53%) were determined to be responders, 25 (44%) were nonresponders, and 2 were not able to be evaluated. Twenty patients died within the 60 days of follow-up. We found that a poor day 45 outcome was associated with patients who had high baseline serum galactomannan (GM) antigen levels and those receiving steroids at the time of IA. A consistently negative serum GM index was associated with a good outcome, and the day 14 clinical evaluation was predictive of the day 45 outcome. No association was found between\n                    <jats:named-content content-type=\"genus-species\">Aspergillus<\/jats:named-content>\n                    antibodies or DNA detection and patients' outcome. We conclude that the GM index value at diagnosis of IA, GM index kinetics, and clinical evaluation at day 14 are good markers for predicting the outcome of patients with IA and should be taken into account for adapting antifungal treatment.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00750-11","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T23:57:46Z","timestamp":1323907066000},"page":"823-830","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":70,"title":["Prospective Evaluation of Clinical and Biological Markers To Predict the Outcome of Invasive Pulmonary Aspergillosis in Hematological Patients"],"prefix":"10.1128","volume":"50","author":[{"given":"Anne","family":"Bergeron","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Service de Pneumologie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Porcher","sequence":"additional","affiliation":[{"name":"UMR-S717 Inserm, Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, D\u00e9partement de Biostatistique et Informatique M\u00e9dicale, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Menotti","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Laboratoire de Parasitologie-Mycologie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Louis","family":"Poirot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 6, AP-HP, Laboratoire de Parasitologie-Mycologie, H\u00f4pital Saint Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Chagnon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Service de Pneumologie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Vekhoff","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 5, AP-HP, Service d'H\u00e9matologie, H\u00f4pital H\u00f4tel Dieu, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Cornet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 5, AP-HP, Service de Microbiologie, H\u00f4pital H\u00f4tel Dieu, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Isnard","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 6, AP-HP, Service d'H\u00e9matologie Clinique, H\u00f4pital Saint Antoine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Raffoux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Service des Maladies du Sang, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Brethon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Service d'H\u00e9matologie P\u00e9diatrique, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Lacroix","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Laboratoire de Parasitologie-Mycologie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Touratier","sequence":"additional","affiliation":[{"name":"Pharmacie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Paul","family":"Latg\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Aspergillus, Institut Pasteur, Paris"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bouges-Michel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris 13, AP-HP, Laboratoire de Parasitologie-Mycologie, H\u00f4pital Avicenne, Bobigny, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdellatif","family":"Tazi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Service de Pneumologie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Derouin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Laboratoire de Parasitologie-Mycologie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ribaud","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, AP-HP, Service d'H\u00e9matologie-Greffe de Moelle, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Sulahian","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Laboratoire de Parasitologie-Mycologie, AP-HP, H\u00f4pital Saint-Louis, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/514352"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/323335"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/339324"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.1.253"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2009.05.058"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.844-846.2004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.02122.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/514341"},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"46","author":"De Pauw B","year":"2008","unstructured":"De PauwB. 2008. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group. Clin. Infect. Dis. 46:1813\u20131821.","journal-title":"Clin. Infect. Dis."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020191"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.334"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70238-3"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0609.2010.01452.x","article-title":"Aspergillus PCR testing: results from a prospective PCR study within the AmBiLoad trial","volume":"85","author":"Hummel M","year":"2010","unstructured":"HummelM. 2010. Aspergillus PCR testing: results from a prospective PCR study within the AmBiLoad trial. Eur. J. Haematol. 85:164\u2013169.","journal-title":"Eur. J. Haematol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/323337"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02281-09"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24022"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22738"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/528714"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.10.5097-5101.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3062.2010.00492.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1086\/592255"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1086\/657065"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.02.002"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1086\/590566"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-004-5495-0"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.499374"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.33.2.497-500.1995"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-268151"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23441"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22863"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00750-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00750-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T18:24:18Z","timestamp":1713205458000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00750-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1128\/JCM.00750-11"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00750-11","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]},"assertion":[{"value":"2011-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}