{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:30:04Z","timestamp":1790515804061,"version":"4.1.0"},"reference-count":53,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Paecilomyces variotii<\/jats:italic>\n                    is a commonly occurring species in air and food, but it is also associated with many types of human infections and is among the emerging causative agents of opportunistic mycoses in immunocompromised hosts.\n                    <jats:italic>Paecilomyces<\/jats:italic>\n                    can cause hyalohyphomycosis, and two species,\n                    <jats:italic>Paecilomyces lilacinus<\/jats:italic>\n                    and\n                    <jats:italic>P. variotii<\/jats:italic>\n                    , are the most frequently encountered organisms. In the present study, a set of 34 clinical isolates morphologically identified as\n                    <jats:italic>P. variotii<\/jats:italic>\n                    or\n                    <jats:italic>P. lilacinus<\/jats:italic>\n                    were formally identified by sequencing intergenic transcribed spacer regions 1 and 2 (including 5.8S rDNA) and a part of the \u03b2-tubulin gene. Three isolates were identified as\n                    <jats:italic>P. lilacinus<\/jats:italic>\n                    , and five of the presumptive\n                    <jats:italic>P. variotii<\/jats:italic>\n                    isolates did not belong to the genus\n                    <jats:italic>Paecilomyces<\/jats:italic>\n                    but were identified as\n                    <jats:italic>Talaromyces eburneus<\/jats:italic>\n                    (anamorph,\n                    <jats:italic>Geosmithia argillacea<\/jats:italic>\n                    ) or\n                    <jats:italic>Hamigera avellanea<\/jats:italic>\n                    (anamorph,\n                    <jats:italic>Merimbla ingelheimense<\/jats:italic>\n                    ). Applying the most recent taxonomy, we found that the clinical\n                    <jats:italic>P. variotii<\/jats:italic>\n                    isolates could be identified as\n                    <jats:italic>P. variotii<\/jats:italic>\n                    sensu stricto (14 strains),\n                    <jats:italic>P. formosus<\/jats:italic>\n                    (11 strains), and\n                    <jats:italic>P. dactylethromorphus<\/jats:italic>\n                    (1 strain). These data indicate that\n                    <jats:italic>P. formosus<\/jats:italic>\n                    occurs in clinical samples as commonly as\n                    <jats:italic>P. variotii<\/jats:italic>\n                    . Susceptibility tests showed that the antifungal susceptibility profiles of\n                    <jats:italic>P. variotii<\/jats:italic>\n                    ,\n                    <jats:italic>P. formosus<\/jats:italic>\n                    , and\n                    <jats:italic>P. dactylethromorphus<\/jats:italic>\n                    are similar and that all strains tested were susceptible to amphotericin B\n                    <jats:italic>in vitro<\/jats:italic>\n                    .\n                    <jats:italic>P. lilanicus<\/jats:italic>\n                    ,\n                    <jats:italic>T. eburneus<\/jats:italic>\n                    , and\n                    <jats:italic>H. avellanea<\/jats:italic>\n                    had different susceptibility profiles; and flucytosine and voriconazole were the least active of the antifungal drugs tested against these species. Our results indicate that correct species identification is important to help guide appropriate antifungal therapy.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00764-10","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T22:51:58Z","timestamp":1275519118000},"page":"2754-2761","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":107,"title":["Identification of\n                    <i>Paecilomyces variotii<\/i>\n                    in Clinical Samples and Settings"],"prefix":"10.1128","volume":"48","author":[{"given":"Jos","family":"Houbraken","sequence":"first","affiliation":[{"name":"CBS-KNAW Fungal Biodiversity Centre, Department of Applied and Industrial Mycology, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthonius J. 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