{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:19:49Z","timestamp":1792495189228,"version":"4.5.0"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Diagnosing malaria using standard techniques is time-consuming. With limited staffing in many laboratories, this may lead to delays in reporting. Innovative technologies are changing the diagnostic landscape and may help alleviate staffing shortages. The miLab MAL, an automated artificial intelligence-driven instrument was compared with standard microscopy at LabCorp reference laboratories. Four hundred eight samples submitted for parasitic examination were prepared with thick and thin smears and Noul\u2019s malaria platform miLab MAL, and evaluated for positivity, negativity, percent positivity, and species identification. Of 408 samples, 399 samples were manually negative, while 397 were negative by miLab MAL. Two samples initially classified as negative manually were found positive by miLab MAL. In all nine cases,\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      was identified by both methods. Percentage parasitemia was higher in the manually calculated method, especially when &gt;1%. miLab MAL was accurate in identifying the absence of\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      and exhibited higher sensitivity than the manual method. All positive samples detected by microscopy were also identified with miLab MAL. All positive\n                      <jats:italic>Plasmodium<\/jats:italic>\n                      cases were correctly identified by miLab MAL. However, the number of positive samples was limited to only\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      . Although parasitemia by the manual method was on average six times higher than with miLab MAL, this may be due to sampling variability. The findings show that miLab MAL can be used to screen out negative\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      samples. Further studies assessing parasitemia between methods and identification of non-falciparum samples are necessary to assess the reliability of this new technology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/jcm.00775-24","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T09:00:43Z","timestamp":1733821243000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["Diagnosis of\n                    <i>Plasmodium<\/i>\n                    infections using artificial intelligence techniques versus standard microscopy in a reference laboratory"],"prefix":"10.1128","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1530-9275","authenticated-orcid":true,"given":"Sanjai","family":"Nagendra","sequence":"first","affiliation":[{"name":"LabCorp","place":["Burlington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxanna","family":"Hayes","sequence":"additional","affiliation":[{"name":"LabCorp","place":["Burlington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1168-1460","authenticated-orcid":true,"given":"Dayeong","family":"Bae","sequence":"additional","affiliation":[{"name":"Noul Co., Ltd.","place":["Yongin, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystin","family":"Dodge","sequence":"additional","affiliation":[{"name":"LabCorp","place":["Burlington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","volume-title":"World malaria report 2022","author":"World Health Organization","year":"2022","unstructured":"World Health Organization. 2022. World malaria report 2022. Geneva."},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7108a1"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7236a1"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7241a3"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-021-03889-7"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/341938"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.1.66-78.2002"},{"key":"e_1_3_1_9_2","first-page":"249","article-title":"A comparative study of thick and thin blood films in the diagnosis of scanty malaria parasitaemia","volume":"34","author":"Dowling MA","year":"1966","unstructured":"Dowling MA, Shute GT. 1966. A comparative study of thick and thin blood films in the diagnosis of scanty malaria parasitaemia. Bull World Health Organ 34:249\u2013267.","journal-title":"Bull World Health Organ"},{"key":"e_1_3_1_10_2","unstructured":"Centers for Disease Control and Prevention. Malaria diagnostic tests. https:\/\/www.cdc.gov\/dpdx\/diagnosticprocedures\/blood\/microexam.html#:~:text=Most%20often%2C%20the%20thin%20smear calling%20a%20thick%20smear%20negative."},{"key":"e_1_3_1_11_2","unstructured":"Stone J. 2022. We\u2019re facing a critical shortage of medical laboratory professionals. Forbes. Available from: www.forbes.com\/sites\/judystone\/2022\/04\/28\/were-facing-a-critical-shortage-of-medical-laboratory-professionals\/?sh=4b1a348f260c"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3626726"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-S17-S18"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1109\/BIBM.2016.7822567"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.2196\/resprot.6758"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0003091"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/644781"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lansea.2022.100054"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmala.2024.1250220"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1392269"},{"key":"e_1_3_1_21_2","volume-title":"Basic malaria microscopy \u2013 Part I: learner\u2019s guide","author":"World Health Organization","unstructured":"World Health Organization. Basic malaria microscopy \u2013 Part I: learner\u2019s guide. 2nd ed. WHO Publications, Geneva.","edition":"2"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.00775-24","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/jcm.00775-24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T09:01:26Z","timestamp":1738314086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/jcm.00775-24"}},"subtitle":[],"editor":[{"given":"Bobbi S.","family":"Pritt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,31]]}},"alternative-id":["10.1128\/jcm.00775-24"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00775-24","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"2024-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00775-24"}}