{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:19:22Z","timestamp":1791674362553,"version":"4.3.4"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The majority of cervical human papillomavirus (HPV) infections in young women are transient, but whether the clearance differs among different HPV genotypes and the different factors predicting genotype-specific clearance are partly unknown. In the Finnish Family HPV Study, 131 of 252 women (mean age, 25.5 years) cleared their infection during the prospective follow-up of 6 years (median, 62.4 months; range, 1.6 to 94.5 months). Cervical scrapings collected at each visit were tested for 24 low-risk and high-risk (HR) HPV types with multiplex HPV genotyping. Poison regression (panel data) was used to estimate predictors for the clearance of species 7 and 9 HPV genotypes. Of all HPV genotypes detected in these women, multiple-type and HPV type 16 (HPV16) infections showed clearance least frequently (46.1% and 50.5%, respectively). The actuarial and crude mean times to first clearance were variable among different genotypes. The actuarial clearance rate (events\/person-time at risk) was highest for HPV16 and multiple-type infections, while HPV66 and -82 had the highest crude clearance rate. Independent predictors increasing type-specific clearance of species 7\/9 HPV genotypes were older age (incidence rate ratio [IRR] = 1.1; 95% confidence interval [95% CI], 1.03 to 1.18;\n            <jats:italic>P<\/jats:italic>\n            = 0.002) and baseline oral HR HPV DNA-negative status (IRR = 2.94; 95% CI, 1.03 to 8.36;\n            <jats:italic>P<\/jats:italic>\n            = 0.042), while a higher number of sexual partners during the follow-up decreased the probability of clearance (IIR = 0.35; 95% CI, 0.15 to 0.83;\n            <jats:italic>P<\/jats:italic>\n            = 0.018). To conclude, HPV16 and multiple-type infections showed the lowest clearance among young mothers. Increasing age and negative oral HR HPV DNA status at baseline were associated with increased clearance, whereas a higher number of current sexual partners decreased the probability of species 7\/9 HPV genotype clearance.\n          <\/jats:p>","DOI":"10.1128\/jcm.00783-10","type":"journal-article","created":{"date-parts":[[2010,6,17]],"date-time":"2010-06-17T01:56:56Z","timestamp":1276739816000},"page":"2665-2671","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["Genotype-Specific Clearance of Genital Human Papillomavirus (HPV) Infections among Mothers in the Finnish Family HPV Study"],"prefix":"10.1128","volume":"48","author":[{"given":"Karolina","family":"Louvanto","sequence":"first","affiliation":[{"name":"Medicity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland"},{"name":"Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari J.","family":"Syrja\u0308nen","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjut A. M.","family":"Rintala","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seija E.","family":"Gre\u0301nman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stina M.","family":"Syrja\u0308nen","sequence":"additional","affiliation":[{"name":"Medicity Research Laboratory and Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5264"},{"key":"e_1_3_2_3_2","unstructured":"Analysis of longitudinal data 1st ed. 1994"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/315086"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/341782"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1380"},{"key":"e_1_3_2_7_2","unstructured":"Generalized estimating equations. 2003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199802123380703"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-06-0846"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23679"},{"key":"e_1_3_2_11_2","unstructured":"J. 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