{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:09:38Z","timestamp":1791155378830,"version":"4.1.0"},"reference-count":44,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>To investigate the impact of pregnancy on human herpesvirus 8 (HHV-8) reactivation in human immunodeficiency virus type 1 (HIV-1)-infected women, the HHV-8 DNA presence and load were analyzed in peripheral blood mononuclear cells (PBMCs) and cervicovaginal secretions (CVSs) from 15 pregnant women coinfected with HIV-1 and HHV-8. HHV-8 detection was analyzed in relation to anti-HHV-8 antibodies and HIV-1-related parameters. Nucleotide sequence analysis of an ORFK1 hypervariable region of the HHV-8 strains was performed. HHV-8 was detected in maternal PBMCs (5\/15 women) from the second trimester and in CVSs (5\/15 women) mainly from the third trimester. The HHV-8 load significantly increased late in pregnancy in both maternal compartments and was associated with a significant increase in HIV-1 shedding in the genital tract. Antilytic antibodies were significantly more common in HHV-8 DNA-positive women. An elevated HHV-8 load was found in the PBMCs of an infant born to a mother with large amounts of HHV-8 in both compartments at delivery. Different ORFK1 subtypes were found in maternal samples, whereas the same subtype was identified in the mother-child pair. These data suggest that pregnancy may induce HHV-8 replication in HIV-1-infected women. An augmented HHV-8 load may, in turn, influence mother-to-child transmission, since one of the HIV-1-infected mothers with HHV-8 reactivation transmitted her ORFK1 subtype to the infant, who showed a high level of HHV-8 viremia indicative of a primary infection. This finding documents for the first time the perinatal transmission of a specific HHV-8 subtype. Vertical transmission may thus play a role in HHV-8 spread also in areas of subendemicity among HIV-1-infected women.<\/jats:p>","DOI":"10.1128\/jcm.00791-06","type":"journal-article","created":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T18:13:36Z","timestamp":1162836816000},"page":"3863-3871","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Pregnancy and Human Herpesvirus 8 Reactivation in Human Immunodeficiency Virus Type 1-Infected Women"],"prefix":"10.1128","volume":"44","author":[{"given":"Andrea","family":"Lisco","sequence":"first","affiliation":[{"name":"Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padua"},{"name":"Clinic of Infectious Diseases, University of Bari, Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Barbierato","sequence":"additional","affiliation":[{"name":"Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0300 R.","family":"Fiore","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gasperini","sequence":"additional","affiliation":[{"name":"Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Favia","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Volpe","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Chironna","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Human Oncology, Hygiene Section, University of Bari, Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pastore","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, University of Bari, Bari"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Chieco-Bianchi","sequence":"additional","affiliation":[{"name":"Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Calabro\u0300","sequence":"additional","affiliation":[{"name":"Istituto Oncologico Veneto, Immunology and Diagnostic Molecular Oncology, Padua, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200210180-00013"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200005260-00028"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/367985"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-831880"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/314765"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000115)85:2<296::AID-IJC23>3.0.CO;2-Q"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.2.154"},{"key":"e_1_3_2_9_2","first-page":"207","volume":"1","year":"1998","unstructured":"Calabr\u00f2, M. 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