{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:24:06Z","timestamp":1790904246871,"version":"4.1.0"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We report a role for\n            <jats:named-content content-type=\"genus-species\">Borrelia microti<\/jats:named-content>\n            as a cause of relapsing fever in Iran supported by robust epidemiological evidence. The molecular identity of this spirochete and its relation with other relapsing fever borreliae have, until now, been poorly delineated. We analyzed an isolate of\n            <jats:named-content content-type=\"genus-species\">B. microti<\/jats:named-content>\n            , obtained from\n            <jats:named-content content-type=\"genus-species\">Ornithodoros erraticus<\/jats:named-content>\n            ticks, by sequencing four loci (16S rRNA,\n            <jats:italic>flaB<\/jats:italic>\n            ,\n            <jats:italic>glpQ<\/jats:italic>\n            , intragenic spacer [IGS]) and comparing these sequences with those of other relapsing fever borreliae. Phylogenetic analysis using concatenated sequences of 16S rRNA,\n            <jats:italic>flaB<\/jats:italic>\n            , and\n            <jats:italic>glpQ<\/jats:italic>\n            grouped\n            <jats:named-content content-type=\"genus-species\">B. microti<\/jats:named-content>\n            alongside three members of the African group,\n            <jats:named-content content-type=\"genus-species\">B. duttonii<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">B. recurrentis<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">B. crocidurae<\/jats:named-content>\n            , which are distinct from\n            <jats:named-content content-type=\"genus-species\">B. persica<\/jats:named-content>\n            , the most prevalent established cause of tick-borne relapsing fever in Iran. The similarity values for 10 concatenated sequences totaling 2,437 nucleotides ranged from 92.11% to 99.84%, with the highest homologies being between\n            <jats:named-content content-type=\"genus-species\">B. duttonii<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">B. microti<\/jats:named-content>\n            and between\n            <jats:named-content content-type=\"genus-species\">B. duttonii<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">B. recurrentis<\/jats:named-content>\n            . Furthermore, the more discriminatory IGS sequence analysis corroborated the close similarity (97.76% to 99.56%) between\n            <jats:named-content content-type=\"genus-species\">B. microti<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">B. duttonii<\/jats:named-content>\n            . These findings raise the possibility that both species may indeed be the same and further dispel the one-species, one-vector theory that has been the basis for classification of relapsing fever\n            <jats:named-content content-type=\"genus-species\">Borrelia<\/jats:named-content>\n            for the last 100 years.\n          <\/jats:p>","DOI":"10.1128\/jcm.00801-12","type":"journal-article","created":{"date-parts":[[2012,6,21]],"date-time":"2012-06-21T13:33:52Z","timestamp":1340285632000},"page":"2873-2876","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Phylogenetic Analysis of the Spirochete Borrelia microti, a Potential Agent of Relapsing Fever in Iran"],"prefix":"10.1128","volume":"50","author":[{"given":"Saied Reza","family":"Naddaf","sequence":"first","affiliation":[{"name":"Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Ghazinezhad","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golnaz","family":"Bahramali","sequence":"additional","affiliation":[{"name":"Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally Jane","family":"Cutler","sequence":"additional","affiliation":[{"name":"School of Health, Sports &amp; Bioscience, University of East London, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02767.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1211.060715"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/vbz.2009.0151"},{"key":"e_1_3_3_5_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-387050-6.50021-9","volume-title":"Biology of parasitic spirochetes","author":"Burgdorfer W","year":"1976","unstructured":"BurgdorferW YorkN. 1976. 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