{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:37:27Z","timestamp":1787499447240,"version":"build-2736575974"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To assess the prevalence and public health significance of rabbit cryptosporidiosis, a total of 1,081 fecal specimens were collected between October 2007 and April 2008 from rabbits on eight farms in five different areas in Henan Province, China, and were examined by microscopy after Sheather's sucrose flotation and modified acid-fast staining. The average infection rate of\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    was 3.4% (37\/1,081 samples). There was a significant association between the prevalence of\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    and the age of animals (\u03c7\n                    <jats:sup>2<\/jats:sup>\n                    = 57.13;\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01); the prevalence of cryptosporidiosis in 1- to 3-month-old rabbits was the highest (10.9%). The\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    species in microscopy-positive specimens were genotyped by sequence analyses of the 18S rRNA, 70-kDa heat shock protein (HSP70), oocyst wall protein (COWP), and actin genes and were subtyped by sequence analysis of the 60-kDa glycoprotein (gp60) gene. Only the\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    rabbit genotype was identified, with 100% sequence identity to published sequences of the 18S rRNA, HSP70, COWP, and actin genes, and the strains belonged to three gp60 subtypes (VbA36, VbA35, and VbA29). In view of the recent finding of the\n                    <jats:italic>Cryptosporidium<\/jats:italic>\n                    rabbit genotype in human outbreak and sporadic cases, the role of rabbits in the transmission of human cryptosporidiosis should be reassessed.\n                  <\/jats:p>","DOI":"10.1128\/jcm.00819-10","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T23:10:02Z","timestamp":1278544202000},"page":"3263-3266","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Prevalence, Genetic Characteristics, and Zoonotic Potential of\n                    <i>Cryptosporidium<\/i>\n                    Species Causing Infections in Farm Rabbits in China"],"prefix":"10.1128","volume":"48","author":[{"given":"Ke","family":"Shi","sequence":"first","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuchuan","family":"Jian","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochao","family":"Lv","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshen","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People's Republic of China"},{"name":"Atlanta Research and Education Foundation, 1670 Clairmont Road, Decatur, Georgia 30033"},{"name":"Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xupeng","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa K.","family":"Dearen","sequence":"additional","affiliation":[{"name":"Atlanta Research and Education Foundation, 1670 Clairmont Road, Decatur, Georgia 30033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Atlanta Research and Education Foundation, 1670 Clairmont Road, Decatur, Georgia 30033"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Qi","sequence":"additional","affiliation":[{"name":"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Xiao","sequence":"additional","affiliation":[{"name":"Atlanta Research and Education Foundation, 1670 Clairmont Road, Decatur, Georgia 30033"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.6.2744-2747.2003"},{"key":"e_1_3_2_3_2","first-page":"3","volume":"2","year":"2008","unstructured":"Anonymous. 2008. Outbreak of cryptosporidiosis associated with a water contamination incident in the East Midlands. Health Prot. Rep. 2 : 3-5.","journal-title":"Health Prot. Rep."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2003.tb00620.x"},{"key":"e_1_3_2_5_2","first-page":"829","volume":"15","year":"2009","unstructured":"Chalmers, R. M., G. Robinson, K. Elwin, S. J. Hadfield, L. Xiao, U. Ryan, D. Modha, and C. Mallaghan. 2009. Cryptosporidium sp. rabbit genotype, a newly identified human pathogen. Emerg. Infect. Dis. 15 : 829-830.","journal-title":"rabbit genotype, a newly identified human pathogen. Emerg. Infect. Dis."},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.03.005"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01034-07"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931279"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.2002.tb00224.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(96)01123-5"},{"key":"e_1_3_2_11_2","first-page":"361","volume":"41","year":"1996","unstructured":"Pavl\u00e1sek, I., M. L\u00e1vicka, E. T\u016fmov\u00e1, and M. Skrivan. 1996. Spontaneous Cryptosporidium infection in weaned rabbits. Vet. Med. (Prague) 41 : 361-366.","journal-title":"Vet. Med. (Prague)"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.07.003"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.080239"},{"key":"e_1_3_2_14_2","unstructured":"The European rabbit (Oryctolagus cuniculus) a source of zoonotic cryptosporidiosis."},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.69.7.4302-4307.2003"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.68.281"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(98)00226-X"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.6.2385-2391.2000"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0388:MPAERO]2.0.CO;2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.6.2805-2809.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.24.4876"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.65.8.3386-3391.1999"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.66.12.5499-5502.2000"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1086\/318090"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(02)00197-2"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.1.72-97.2004"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2008.03.006"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2009.03.018"},{"key":"e_1_3_2_29_2","first-page":"114","volume":"12","year":"1992","unstructured":"Zhang, X. C., L. S. Hu, and D. C. Li. 1992. Study on some biologic properties of Cryptosporidium. Bull. P. L. A. Vet. Coll. 12 : 114-118. (In Chinese.)","journal-title":"Bull. P. L. A. Vet. 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