{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:02:13Z","timestamp":1761580933944},"reference-count":34,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The plasticity region of\n            <jats:named-content content-type=\"genus-species\">Helicobacter pylori<\/jats:named-content>\n            is a large chromosomal segment including isolate-specific open reading frames with characteristics of pathogenicity islands. It remains unclear whether genes in the plasticity region play a role in the pathogenesis of gastric mucosal inflammation and gastroduodenal disease. Our aim was to assess the role of selected genes in the plasticity region in relation to risk of\n            <jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>\n            -related disease and the severity of gastric mucosal damage. We used PCR to study the relation of disease outcome and mucosal damage with four genes in the\n            <jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>\n            plasticity region (\n            <jats:italic>jhp0940<\/jats:italic>\n            ,\n            <jats:italic>jhp0945<\/jats:italic>\n            ,\n            <jats:italic>jhp0947<\/jats:italic>\n            , and\n            <jats:italic>jhp0949<\/jats:italic>\n            ) from isolates obtained from both Western (\n            <jats:italic>n<\/jats:italic>\n            = 296) and East Asian (\n            <jats:italic>n<\/jats:italic>\n            = 217) patients. The prevalence of\n            <jats:italic>jhp0945<\/jats:italic>\n            ,\n            <jats:italic>jhp0947<\/jats:italic>\n            , and\n            <jats:italic>jhp0949<\/jats:italic>\n            differed significantly between Western and East Asian isolates. In Western isolates, the presence of\n            <jats:italic>jhp0945<\/jats:italic>\n            was significantly associated with gastric ulcer, duodenal ulcer, and gastric cancer (odds ratios [95% confidence intervals]: 2.27 [1.04 to 4.98], 1.86 [1.03 to 3.34], and 1.92 [1.03 to 3.56], respectively).\n            <jats:italic>jhp0940<\/jats:italic>\n            -positive Western isolates were significantly associated with absence of gastric ulcer or duodenal ulcer (0.21 [0.05 to 0.94] and 0.31 [0.12 to 0.78], respectively). No significant difference was observed between inflammatory cell infiltration or atrophy and the presence or absence of plasticity region genes. The outcome of\n            <jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>\n            infections varies widely geographically. These data suggest a possible role for difference in the prevalence of plasticity region genes in the geographic variation in\n            <jats:named-content content-type=\"genus-species\">H. pylori<\/jats:named-content>\n            -related diseases.\n          <\/jats:p>","DOI":"10.1128\/jcm.00906-11","type":"journal-article","created":{"date-parts":[[2011,11,25]],"date-time":"2011-11-25T01:14:27Z","timestamp":1322183667000},"page":"441-448","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":19,"title":["Role of Helicobacter pylori Plasticity Region Genes in Development of Gastroduodenal Diseases"],"prefix":"10.1128","volume":"50","author":[{"given":"Mitsushige","family":"Sugimoto","sequence":"first","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA"},{"name":"First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Watada","sequence":"additional","affiliation":[{"name":"Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Woo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA"},{"name":"Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David Y.","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Yamaoka","sequence":"additional","affiliation":[{"name":"Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas, USA"},{"name":"Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/16495"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001099900067"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.30.17771"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70223-3"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.12.5791"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.femsim.2004.03.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/35006081"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(96)90135-5"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34156"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.36589"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010043"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37043"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.11.3210-3218.2000"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1010153107"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.028811"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.11.6240-6249.2000"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2007.03.019"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.056"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01309-07"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01284-08"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.26.14668"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2007.03.002"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.4.1651-1655.2003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2011.03.002"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm074"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02769.x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.5.1799-1809.1993"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70365-8"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2010.4.3.345"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/000570-0"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.8.2258-2263.1998"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130079797"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)02617-0"}],"container-title":["Journal of Clinical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00906-11","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/JCM.00906-11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,5]],"date-time":"2022-03-05T11:02:07Z","timestamp":1646478127000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/JCM.00906-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1128\/JCM.00906-11"],"URL":"https:\/\/doi.org\/10.1128\/jcm.00906-11","relation":{},"ISSN":["0095-1137","1098-660X"],"issn-type":[{"value":"0095-1137","type":"print"},{"value":"1098-660X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2]]},"assertion":[{"value":"2011-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2011-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}