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Important new developments include validation of 24-h reading times for all antifungal agents and the establishment of species-specific epidemiological cutoff values (ECVs) for the systemically active antifungal agents and both common and uncommon species of\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            . The clinical breakpoints (CBPs) for fluconazole, voriconazole, and the echinocandins have been revised to provide species-specific interpretive criteria for the six most common species. The revised CBPs not only are predictive of clinical outcome but also provide a more sensitive means of identifying those strains with acquired or mutational resistance mechanisms. This brief review serves as an update on the new developments in the antifungal susceptibility testing of\n            <jats:named-content content-type=\"genus-species\">Candida<\/jats:named-content>\n            spp. using Clinical and Laboratory Standards Institute (CLSI) broth microdilution (BMD) methods.\n          <\/jats:p>","DOI":"10.1128\/jcm.00937-12","type":"journal-article","created":{"date-parts":[[2012,6,28]],"date-time":"2012-06-28T04:32:19Z","timestamp":1340857939000},"page":"2846-2856","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":400,"title":["Progress in Antifungal Susceptibility Testing of Candida spp. by Use of Clinical and Laboratory Standards Institute Broth Microdilution Methods, 2010 to 2012"],"prefix":"10.1128","volume":"50","author":[{"given":"M. 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