{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:47:55Z","timestamp":1791143275922,"version":"4.1.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["J Clin Microbiol"],"published-print":{"date-parts":[[2012,12]]},"abstract":"ABSTRACT<\/jats:title>We conducted active, laboratory-based surveillance for isolates from patients with invasive infections across China from August 2009 to July 2010. DNA sequencing methods were used to define species, and susceptibility to fluconazole and voriconazole was determined by the Clinical and Laboratory Standards Institute M44-A2 disk diffusion method but using up-to-date clinical breakpoints or epidemiological cutoff values.Candida<\/jats:named-content>spp. made up 90.5% of the 814 yeast strains isolated, followed byCryptococcus neoformans<\/jats:named-content>(7.7%) and other non-Candida<\/jats:named-content>yeast strains (1.7%). Bloodstream isolates made up 42.9% of the strains, isolates from ascitic fluid made up 22.1%, but pus\/tissue specimens yielded yeast strains in <5% of the cases. Among theCandida<\/jats:named-content>isolates,Candida albicans<\/jats:named-content>was the most common species from specimens other than blood (50.1%) but made up only 23% of the bloodstream isolates (P<\/jats:italic>< 0.001).C. parapsilosis<\/jats:named-content>complex species were the most commonCandida<\/jats:named-content>isolates from blood (33.2%). Uncommon bloodstream yeast strains includedTrichosporon<\/jats:named-content>spp.,C. pelliculosa<\/jats:named-content>, and the novel speciesC. quercitrusa<\/jats:named-content>, reported for the first time as a cause of candidemia. Most (>94%) of the isolates ofC. albicans<\/jats:named-content>,C. tropicalis<\/jats:named-content>, and theC. parapsilosis<\/jats:named-content>complex were susceptible to fluconazole and voriconazole, as were all of theTrichosporon<\/jats:named-content>strains; however, 12.2% of theC. glabrata sensu stricto<\/jats:named-content>isolates were fluconazole resistant and 17.8% had non-wild-type susceptibility to voriconazole. SevenC. tropicalis<\/jats:named-content>strains were cross-resistant to fluconazole and voriconazole; six were from patients in the same institution. Resistance to fluconazole and voriconazole was seen in 31.9% and 13.3% of the uncommonCandida<\/jats:named-content>and non-Candida<\/jats:named-content>yeast strains, respectively. Causative species and azole susceptibility varied with the geographic region. This study provided clinically useful data on yeast strains and their antifungal susceptibilities in China.<\/jats:p>","DOI":"10.1128\/jcm.01130-12","type":"journal-article","created":{"date-parts":[[2012,10,4]],"date-time":"2012-10-04T05:36:11Z","timestamp":1349328971000},"page":"3952-3959","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":94,"title":["In Vitro<\/i>Susceptibilities of Yeast Species to Fluconazole and Voriconazole as Determined by the 2010 National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study"],"prefix":"10.1128","volume":"50","author":[{"given":"He","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China"},{"name":"Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon C.-A.","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Darcy Road, Westmead, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanrong","family":"Kong","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital, Darcy Road, Westmead, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Feng","family":"Shao","sequence":"additional","affiliation":[{"name":"Institute of Clinical Laboratory Medicine of PLA, Nanjing General Hospital, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking University First Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Fan","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Microbiology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Dong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Tianjin Medical University General Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Zhuo","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Hospital of China Medical University, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tie-Shi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The People's Hospital of Liaoning Province, Shenyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xing","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infection Control, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Ling","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 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